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Treatment with Para...
Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate
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- Adoberg, Annika (författare)
- North Estonia Med Ctr, Estonia
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- Paats, Joosep (författare)
- Tallinn Univ Technol, Estonia
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- Arund, Jurgen (författare)
- Tallinn Univ Technol, Estonia
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- Dhondt, Annemieke (författare)
- Ghent Univ Hosp, Belgium
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- Fridolin, Ivo (författare)
- Tallinn Univ Technol, Estonia
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- Glorieux, Griet (författare)
- Ghent Univ Hosp, Belgium
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- Holmar, Jana (författare)
- Tallinn Univ Technol, Estonia
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- Lauri, Kai (författare)
- Synlab Eesti OU, Estonia
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- Leis, Liisi (författare)
- North Estonia Med Ctr, Estonia
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- Luman, Merike (författare)
- North Estonia Med Ctr, Estonia; Tallinn Univ Technol, Estonia
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- Pilt, Kristjan (författare)
- Tallinn Univ Technol, Estonia
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- Uhlin, Fredrik (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Tallinn Univ Technol, Estonia
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- Tanner, Risto (författare)
- Tallinn Univ Technol, Estonia
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(creator_code:org_t)
- 2022-09-01
- 2022
- Engelska.
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Ingår i: Toxins. - : MDPI. - 2072-6651. ; 14:9
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Optical online methods are used to monitor the haemodialysis treatment efficiency of end stage kidney disease (ESKD) patients. The aim of this study was to analyse the effect of the administration of UV-absorbing drugs, such as paracetamol (Par), on the accuracy of optical monitoring the removal of uremic toxins uric acid (UA) and indoxyl sulfate (IS) during standard haemodialysis (HD) and haemodiafiltration (HDF) treatments. Nine patients received Par in daily dosages 1-4 g for 30 sessions. For 137 sessions, in 36 patients the total daily dosage of UV-absorbing drugs was less than 500 mg, and for 6 sessions 3 patients received additional UV-absorbing drugs. Par administration slightly affected the accuracy of optically assessed removal of UA expressed as bias between optically and laboratory-assessed reduction ratios (RR) during HD but not HDF employing UV absorbance of spent dialysate (p < 0.05) at 295 nm wavelength with the strongest correlation between the concentration of UA and absorbance. Corresponding removal of IS based on fluorescence at Ex280/Em400 nm during HD and HDF was not affected. Administration of UV-absorbing drugs may in some settings influence the accuracy of optical assessments in spent dialysate of the removal of uremic solutes during haemodialysis treatment of ESKD patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- haemodialysis; indoxyl sulfate; optical monitoring; paracetamol; uric acid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Toxins
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Adoberg, Annika
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Paats, Joosep
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Arund, Jurgen
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Dhondt, Annemiek ...
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Fridolin, Ivo
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Glorieux, Griet
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visa fler...
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Holmar, Jana
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Lauri, Kai
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Leis, Liisi
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Luman, Merike
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Pilt, Kristjan
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Uhlin, Fredrik
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Tanner, Risto
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Toxins
- Av lärosätet
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Linköpings universitet