Sökning: id:"swepub:oai:DiVA.org:liu-196748" > Post-COVID sequelae...
Fältnamn | Indikatorer | Metadata |
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000 | 03815naa a2200409 4500 | |
001 | oai:DiVA.org:liu-196748 | |
003 | SwePub | |
008 | 230822s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:153184956 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1967482 URI |
024 | 7 | a https://doi.org/10.3389/fmed.2023.12081812 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1531849562 URI |
040 | a (SwePub)liud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hannestad, Ulfu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)ulfha46 |
245 | 1 0 | a Post-COVID sequelae effect in chronic fatigue syndrome: SARS-CoV-2 triggers latent adenovirus in the oral mucosa |
264 | 1 | b FRONTIERS MEDIA SA,c 2023 |
338 | a electronic2 rdacarrier | |
520 | a The post-viral fatigue syndromes long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have multiple, potentially overlapping, pathological processes. These include persisting reservoirs of virus, e.g., SARS-CoV-2 in long COVID patients tissues, immune dysregulation with or without reactivation of underlying pathogens, such as Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV6), as we recently described in ME/CFS, and possibly yet unidentified viruses. In the present study we tested saliva samples from two cohorts for IgG against human adenovirus (HAdV): patients with ME/CFS (n = 84) and healthy controls (n = 94), with either mild/asymptomatic SARS-CoV-2 infection or no infection. A significantly elevated anti-HAdV IgG response after SARS-CoV-2 infection was detected exclusively in the patient cohort. Longitudinal/time analysis, before and after COVID-19, in the very same individuals confirmed HAdV IgG elevation after. In plasma there was no HAdV IgG elevation. We conclude that COVID-19 triggered reactivation of dormant HAdV in the oral mucosa of chronic fatigue patients indicating an exhausted dysfunctional antiviral immune response in ME/CFS, allowing reactivation of adenovirus upon stress encounter such as COVID-19. These novel findings should be considered in clinical practice for identification of patients that may benefit from therapy that targets HAdV as well. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a post-COVID condition; SARS-CoV-2; myalgic encephalomyelitis; chronic fatigue syndrome; ME; CFS; human adenovirus (HAdV); saliva antibodies; oral mucosa immune response | |
700 | 1 | a Apostolou, Eiriniu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)eirap47 |
700 | 1 | a Sjogren, Peru Karolinska Inst, Sweden; Bragee Clin, Sweden4 aut |
700 | 1 | a Bragee, Bjornu Karolinska Inst, Sweden; Bragee Clin, Sweden4 aut |
700 | 1 | a Polo, Olliu Bragee Clin, Sweden4 aut |
700 | 1 | a Bertilson, Bo Christeru Karolinska Inst, Sweden; Bragee Clin, Sweden4 aut |
700 | 1 | a Rosén, Andersu Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten4 aut0 (Swepub:liu)andro72 |
710 | 2 | a Linköpings universitetb Avdelningen för cellbiologi4 org |
773 | 0 | t Frontiers in Medicined : FRONTIERS MEDIA SAg 10q 10x 2296-858X |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1790287/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196748 |
856 | 4 8 | u https://doi.org/10.3389/fmed.2023.1208181 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:153184956 |
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