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Applications of Bor...
Applications of Boron Cluster Supramolecular Frameworks as Metal-Free Chemodynamic Therapy Agents for Melanoma
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- Xu, Xiaoran (author)
- Wuhan Univ, Peoples R China
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- Deng, Xuefan (author)
- Wuhan Univ, Peoples R China
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- Li, Yi (author)
- Wuhan Univ, Peoples R China
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- Xia, Shiying (author)
- Wuhan Univ, Peoples R China
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- Baryshnikov, Glib (author)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Bondarchuk, Sergey V. (author)
- Bogdan Khmelnitsky Cherkasy Natl Univ, Ukraine
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- Agren, Hans (author)
- Uppsala Univ, Sweden
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- Wang, Xinyu (author)
- Wuhan Univ, Peoples R China
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- Liu, Pan (author)
- Wuhan Univ, Peoples R China
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- Tan, Yujia (author)
- Wuhan Univ, Peoples R China
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- Huang, Tianhe (author)
- Wuhan Univ, Peoples R China
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- Zhang, Haibo (author)
- Wuhan Univ, Peoples R China
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- Wei, Yongchang (author)
- Wuhan Univ, Peoples R China
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: Small. - : WILEY-V C H VERLAG GMBH. - 1613-6810 .- 1613-6829.
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Chemodynamic therapy (CDT) is a highly targeted approach to treat cancer since it converts hydrogen peroxide into harmful hydroxyl radicals (OH & BULL;) through Fenton or Fenton-like reactions. However, the systemic toxicity of metal-based CDT agents has limited their clinical applications. Herein, a metal-free CDT agent: 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT)/ [closo-B12H12]2-(TPT@ B12H12) is reported. Compared to the traditional metal-based CDT agents, TPT@B12H12 is free of metal avoiding cumulative toxicity during long-term therapy. Density functional theory (DFT) calculation revealed that TPT@B12H12 decreased the activation barrier more than 3.5 times being a more effective catalyst than the Fe2+ ion (the Fenton reaction), which decreases the barrier about twice. Mechanismly, the theory calculation indicated that both [B12H12]-& BULL; and [TPT-H]2+ have the capacity to decompose hydrogen into 1O2, OH & BULL;, and O2-& BULL;. With electron paramagnetic resonance and fluorescent probes, it is confirmed that TPT@B12H12 increases the levels of 1O2, OH & BULL;, and O2-& BULL;. More importantly, TPT@B12H12 effectively suppress the melanoma growth both in vitro and in vivo through 1O2, OH & BULL;, and O2-& BULL; generation. This study specifically highlights the great clinical translational potential of TPT@B12H12 as a CDT reagent. 2,4,6-Tri(4-pyridyl)-1,3,5-triazine (TPT)/ [closo-B12H12]2-(TPT@B12H12), a metal-free chemodynamic therapy (CDT) agent, decreases the activation barrier more than 3.5 times being a more effective catalyst than the Fe2+ ion (the Fenton reaction), which decreases the barrier about twice. More importantly, TPT@B12H12 effectively suppress the melanoma growth both in vitro and in vivo through 1O2, OH & BULL;, and O2-& BULL; generation. image
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- boron cluster supramolecular frameworks; chemodynamic therapy; fenton-like catalytic activity; melanoma
Publication and Content Type
- ref (subject category)
- art (subject category)
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Small
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- By the author/editor
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Xu, Xiaoran
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Deng, Xuefan
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Li, Yi
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Xia, Shiying
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Baryshnikov, Gli ...
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Bondarchuk, Serg ...
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Agren, Hans
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Wang, Xinyu
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Liu, Pan
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Tan, Yujia
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Huang, Tianhe
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Zhang, Haibo
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Wei, Yongchang
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Small
- By the university
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Linköping University