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Sökning: id:"swepub:oai:DiVA.org:liu-199247" > In vivo neuromodula...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003661naa a2200385 4500
001oai:DiVA.org:liu-199247
003SwePub
008231122s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1992472 URI
0247 a https://doi.org/10.1126/sciadv.adi54882 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Tommasini, Giuseppinau CNR, Italy; Univ Zaragoza, Spain4 aut
2451 0a In vivo neuromodulation of animal behavior with organic semiconducting oligomers
264 1b AMER ASSOC ADVANCEMENT SCIENCE,c 2023
338 a print2 rdacarrier
500 a Funding Agencies|Air Force Office of Scientific Research [FA8655-22-1-7014]; European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program "LINCE" [803621]; European Union (ERC-2021-STG, 4DPhytoHybrid) [101042148]; Swedish Government Strategic Research Area in Materials Science on Advanced Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]
520 a Modulating neural activity with electrical or chemical stimulus can be used for fundamental and applied research. Typically, neuronal stimulation is performed with intracellular and extracellular electrodes that deliver brief electrical pulses to neurons. However, alternative wireless methodologies based on functional materials may allow clinical translation of technologies to modulate neuronal function. Here, we show that the organic semiconducting oligomer 4-[2-{2,5-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)thiophen-3-yl}ethoxy]butane-1-sulfonate (ETE-S) induces precise behaviors in the small invertebrate Hydra, which were dissected through pharmacological and electrophysiological approaches. ETE-S-induced behavioral response relies on the presence of head neurons and calcium ions and is prevented by drugs targeting ionotropic channels and muscle contraction. Moreover, ETE-S affects Hydras electrical activity enhancing the contraction burst frequency. The unexpected neuromodulatory function played by this conjugated oligomer on a simple nerve net opens intriguing research possibilities on fundamental chemical and physical phenomena behind organic bioelectronic interfaces for neuromodulation and on alternative methods that could catalyze a wide expansion of this rising technology for clinical applications.
650 7a TEKNIK OCH TEKNOLOGIERx Materialteknikx Textil-, gummi- och polymermaterial0 (SwePub)205042 hsv//swe
650 7a ENGINEERING AND TECHNOLOGYx Materials Engineeringx Textile, Rubber and Polymeric Materials0 (SwePub)205042 hsv//eng
7001 a De Simone, Mariarosariau CNR, Italy4 aut
7001 a Santillo, Silviau CNR, Italy4 aut
7001 a Dufil, Gwennaelu Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten4 aut0 (Swepub:liu)gwedu34
7001 a Iencharelli, Marikau CNR, Italy4 aut
7001 a Mantione, Danieleu POLYMAT Univ Basque Country UPV EHU, Spain; Basque Fdn Sci, Spain4 aut
7001 a Stavrinidou, Eleniu Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten4 aut0 (Swepub:liu)elest58
7001 a Tino, Angelau CNR, Italy4 aut
7001 a Tortiglione, Claudiau CNR, Italy4 aut
7102 a CNR, Italy; Univ Zaragoza, Spainb CNR, Italy4 org
7730 t Science Advancesd : AMER ASSOC ADVANCEMENT SCIENCEg 9:42q 9:42x 2375-2548
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-199247
8564 8u https://doi.org/10.1126/sciadv.adi5488

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