SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:DiVA.org:liu-199259"
 

Sökning: id:"swepub:oai:DiVA.org:liu-199259" > Deciphering early h...

Deciphering early human pancreas development at the single-cell level

Ma, Zhuo (författare)
Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China
Zhang, Xiaofei (författare)
Chinese Acad Sci, Peoples R China; Huazhong Univ Sci & Technol, Peoples R China; Hainan Med Univ, Peoples R China
Zhong, Wen (författare)
Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten,Karolinska Inst, Sweden,Science for Life Laboratory
visa fler...
Yi, Hongyan (författare)
Hainan Med Univ, Peoples R China
Chen, Xiaowei (författare)
Chinese Acad Sci, Peoples R China
Zhao, Yinsuo (författare)
Chinese Acad Sci, Peoples R China
Ma, Yanlin (författare)
Hainan Med Univ, Peoples R China
Song, Eli (författare)
Chinese Acad Sci, Peoples R China
Xu, Tao (författare)
Chinese Acad Sci, Peoples R China; Univ Chinese Acad Sci, Peoples R China; Guangzhou Lab, Peoples R China; Shandong First Med Univ, Peoples R China; Shandong First Med Univ, Peoples R China; Shandong Acad Med Sci, Peoples R China
visa färre...
 (creator_code:org_t)
NATURE PORTFOLIO, 2023
2023
Engelska.
Ingår i: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 14:1
Relaterad länk:
https://urn.kb.se/re...
visa fler...
https://doi.org/10.1...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Understanding pancreas development can provide clues for better treatments of pancreatic diseases. However, the molecular heterogeneity and developmental trajectory of the early human pancreas are poorly explored. Here, we performed large-scale single-cell RNA sequencing and single-cell assay for transposase accessible chromatin sequencing of human embryonic pancreas tissue obtained from first-trimester embryos. We unraveled the molecular heterogeneity, developmental trajectories and regulatory networks of the major cell types. The results reveal that dorsal pancreatic multipotent cells in humans exhibit different gene expression patterns than ventral multipotent cells. Pancreato-biliary progenitors that generate ventral multipotent cells in humans were identified. Notch and MAPK signals from mesenchymal cells regulate the differentiation of multipotent cells into trunk and duct cells. Notably, we identified endocrine progenitor subclusters with different differentiation potentials. Although the developmental trajectories are largely conserved between humans and mice, some distinct gene expression patterns have also been identified. Overall, we provide a comprehensive landscape of early human pancreas development to understand its lineage transitions and molecular complexity. Here, the authors revealed molecular heterogeneity, developmental trajectory and regulatory network of early human pancreas development, and depict the whole progression of pancreatic organogenesis during the first trimester at the single-cell level.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy