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Bioactive, antioxid...
Bioactive, antioxidant and antimicrobial properties of chemically fingerprinted essential oils extracted from Eucalyptus globulus: in-vitro and in-silico investigations
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- Shah, Said Nasir (författare)
- Abbottabad Univ Sci & Technol, Pakistan
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- Khan, Ibrar (författare)
- Abbottabad Univ Sci & Technol, Pakistan
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- Muntaha, Sidra Tul (författare)
- Abbottabad Univ Sci & Technol, Pakistan
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- Hayat, Azam (författare)
- Abbottabad Univ Sci & Technol, Pakistan
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- Rehman, Mujaddad Ur (författare)
- Abbottabad Univ Sci & Technol, Pakistan
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- Ali Shah, Tawaf (författare)
- Univ Okara, Pakistan
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- Siddique, Farhan (författare)
- Linköpings universitet,Laboratoriet för organisk elektronik,Tekniska fakulteten
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- Salamatullah, Ahmad Mohammad (författare)
- King Saud Univ, Saudi Arabia
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- Mekonnen, Amare Bitew (författare)
- Bahir Dar Univ, Ethiopia
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- Bourhia, Mohammed (författare)
- Ibn Zohr Univ, Morocco
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(creator_code:org_t)
- FRONTIERS MEDIA SA, 2023
- 2023
- Engelska.
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Ingår i: Frontiers in Chemistry. - : FRONTIERS MEDIA SA. - 2296-2646. ; 11
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Innovative approaches are urgently required to treat divestating bacterial diseases in the face of rising bacterial resistance rates. The current investigative work focused on hydro-distilling Tasmanian blue gum (Eucalyptus globulus) to isolate the essential oil, which was then tested for bioactivity, antioxidant capacity, and antibacterial activity using in-vitro and in silico assays. The antioxidant activity was avualated against DPPH and FRAP. With results of 69.63 RSA (%) (mu L/L AAE) at a concentration of 5 mL/L and 51.56 (mu L/L AAE) at concentration of 90 ppm in the 2,20-diphenyl-1-picryl hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays, respectively, the extracted oil indicated considerable antioxidant activity. The extracted oil demonstrated powerful antibacterial activity in in-vitro tests against both Gram-positive and Gram-negative bacterial strains, including Bordetella bronchiseptica (21 mm), Staphylococcus epidermidis (19 mm), and Staphylococcus aureus (19 mm), with significant minimal inhibitory (MIC) and minimum bactericidal (MIB) concentrations. Additionally, GC-MS analysis of the oil from E. globulus identified several low-molecular-weight compounds, including Eucalyptol, gamma-Terpinene, Shisool acetate, 1,3-trans,5-cis-Octatriene, 2,6-Dimethyl-1,3,5,7-octatetraene, E,E, Cyclohexene, 1-methyl-4-(1-methylethylidene), Benzene, 1-methyl-4-(1-methylethenyl), Butanoic acid, 3-methyl-, 3-methylbutyl ester, and 1,3,8-p-Menthatriene. Several other compounds were also identified, including Fenchol, 2-Methyl-trans-3a,4,7,7a-tetrahydroindane, (E,E,E)-2,4,6-Octatriene, 1,2,3,6-Tetrahydrobenzylalcohol, acetate, Alloaromadendrene, Phenol, 2-ethyl-4,5-dimethyl, Phenol, 2-methyl-5-(1-methylethyl)-, p-Cymen-7-ol, 1,5,5-Trimethyl-6-methylene-cyclohexene, 1,3-Cyclohexadiene, 1-methyl-4-(1-methylethyl)-, 2,6-Octadien-1-ol, 3,7-dimethyl-, acetate, (Z), and more. The bioactive potential of Eucalyptus globulus essential oil against 1AJ6 and 1R4U was highlighted by molecular docking analyses, suggesting its utility as a natural source of antioxidant and antibacterial compounds with the potential to replace chemical disinfectants in a variety of applications.
Ämnesord
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- essential oils; Eucalyptus; disinfectants; GC-MS; molecular docking
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- ref (ämneskategori)
- art (ämneskategori)
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Shah, Said Nasir
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Khan, Ibrar
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Muntaha, Sidra T ...
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Hayat, Azam
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Rehman, Mujaddad ...
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Ali Shah, Tawaf
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Siddique, Farhan
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Salamatullah, Ah ...
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Mekonnen, Amare ...
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Bourhia, Mohamme ...
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- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Mikrobiologi
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Frontiers in Che ...
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Linköpings universitet