Sökning: id:"swepub:oai:DiVA.org:liu-25965" > Apolipoprotein A-I–...
Fältnamn | Indikatorer | Metadata |
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000 | 02743naa a2200313 4500 | |
001 | oai:DiVA.org:liu-25965 | |
003 | SwePub | |
008 | 091008s2001 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-259652 URI |
040 | a (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mucchiano, Gerd I.u Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet4 aut |
245 | 1 0 | a Apolipoprotein A-I–Derived Amyloid in Atherosclerosis :b Its Association With Plasma Levels of Apolipoprotein A-I and Cholesterol |
264 | 1 | c 2001 |
338 | a print2 rdacarrier | |
520 | a Wild-type apolipoprotein A-I (apo A-I)–derived amyloid commonly occurs in atherosclerotic plaques. To clarify apo A-I amyloid formation, plasma levels of apo A-I and cholesterol were related to the presence of amyloid in atherosclerotic plaques in 15 patients with peripheral atherosclerosis, subjected to arterial reconstruction. Plasma levels of apo A-I and high-density lipoprotein (HDL) cholesterol were slightly higher in patients with apo A-I–derived amyloid than in those without, but the difference was not significant. Levels of low-density lipoprotein cholesterol and total cholesterol were significantly higher in the group with amyloid. High concentrations of apo A-I in the arterial intima are probably of greater importance to amyloid formation than high plasma levels of the protein. During atherosclerosis, the acute phase reactant serum amyloid A may displace apo A-I from HDL, leading to increased concentration of lipid-free apo A-I in the intima and conformational changes of apo A-I, which make it more fibrillogenic. Some forms of amyloid fibrils have been shown to be cytotoxic. Apo AI–derived amyloid is possibly a pathogenically important factor in atherosclerosis. | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Jonasson, Lenau Department of Medicine, Högland Hospital, Eksjö4 aut |
700 | 1 | a Häggqvist, Bo,d 1962-u Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet4 aut0 (Swepub:liu)boha34 |
700 | 1 | a Einarsson, Eibertu Department of Surgery, Högland Hospital, Eksjö4 aut |
700 | 1 | a Westermark, Peru Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet4 aut |
710 | 2 | a Linköpings universitetb Molekylär och immunologisk patologi4 org |
773 | 0 | t American Journal of Clinical Pathologyg 115, s. 298-303q 115<298-303x 0002-9173x 1943-7722 |
856 | 4 | u http://ajcp.ascpjournals.org/content/115/2/298.abstracty Full-text |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25965 |
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