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Sökning: id:"swepub:oai:DiVA.org:liu-25965" > Apolipoprotein A-I–...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00002743naa a2200313 4500
001oai:DiVA.org:liu-25965
003SwePub
008091008s2001 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-259652 URI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Mucchiano, Gerd I.u Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet4 aut
2451 0a Apolipoprotein A-I–Derived Amyloid in Atherosclerosis :b Its Association With Plasma Levels of Apolipoprotein A-I and Cholesterol
264 1c 2001
338 a print2 rdacarrier
520 a Wild-type apolipoprotein A-I (apo A-I)–derived amyloid commonly occurs in atherosclerotic plaques. To clarify apo A-I amyloid formation, plasma levels of apo A-I and cholesterol were related to the presence of amyloid in atherosclerotic plaques in 15 patients with peripheral atherosclerosis, subjected to arterial reconstruction. Plasma levels of apo A-I and high-density lipoprotein (HDL) cholesterol were slightly higher in patients with apo A-I–derived amyloid than in those without, but the difference was not significant. Levels of low-density lipoprotein cholesterol and total cholesterol were significantly higher in the group with amyloid. High concentrations of apo A-I in the arterial intima are probably of greater importance to amyloid formation than high plasma levels of the protein. During atherosclerosis, the acute phase reactant serum amyloid A may displace apo A-I from HDL, leading to increased concentration of lipid-free apo A-I in the intima and conformational changes of apo A-I, which make it more fibrillogenic. Some forms of amyloid fibrils have been shown to be cytotoxic. Apo AI–derived amyloid is possibly a pathogenically important factor in atherosclerosis.
653 a MEDICINE
653 a MEDICIN
700a Jonasson, Lenau Department of Medicine, Högland Hospital, Eksjö4 aut
700a Häggqvist, Bo,d 1962-u Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet4 aut0 (Swepub:liu)boha34
700a Einarsson, Eibertu Department of Surgery, Högland Hospital, Eksjö4 aut
700a Westermark, Peru Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet4 aut
710a Linköpings universitetb Molekylär och immunologisk patologi4 org
773t American Journal of Clinical Pathologyg 115, s. 298-303q 115<298-303x 0002-9173x 1943-7722
856u http://ajcp.ascpjournals.org/content/115/2/298.abstracty Full-text
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25965

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