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Sökning: id:"swepub:oai:DiVA.org:liu-45639" > A pH-induced modifi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003220naa a2200433 4500
001oai:DiVA.org:liu-45639
003SwePub
008091011s2004 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1961711
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-456392 URI
0247 a https://doi.org/10.1016/j.jaut.2004.05.0022 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19617112 URI
040 a (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lundberg, K.u Karolinska Institutet4 aut
2451 0a A pH-induced modification of CII increases its arthritogenic properties
264 1b Elsevier BV,c 2004
338 a print2 rdacarrier
520 a Immunoreactivity to collagen type II (CII) has been implicated in the pathogenesis of rheumatoid arthritis. Patients have been described to have an acidic pH in their inflamed synovial tissue. It is known that protein structures are modified by environmental pH, thus it is plausible that changes in synovial pH could affect the conformation of proteins like CII. Posttranslational modifications could alter the biophysical properties of cartilage proteins leading to autoimmunity. In this study we investigated if arthritogenicity of CII was affected by changes in pH, and if so, this could be correlated to altered protein conformation. Immunisation with CII at neutral pH induced a milder disease than did CII at acidic pH. All animals elicited a humoral response to CII, although with a significantly higher IgG1/IgG2b-ratio in the pH 7.4 group. Analysis by circular dichroism and electron microscopy indicated less fibrillation of CII at low pH as compared to neutral pH. Our results suggest that CII is more immunogenic and arthritogenic in an acidic environment than in a neutral environment. We can correlate these findings to pH-induced conformational changes of CII. Hence, self-tolerance to CII might be affected by changes in pH leading to altered and increased arthritogenicity. © 2004 Elsevier Ltd. All rights reserved.
653 a Arthritis
653 a Collagen type II
653 a Modification
653 a pH
653 a Rat
653 a TECHNOLOGY
653 a TEKNIKVETENSKAP
7001 a Ottosson, L.u Karolinska Institutet4 aut
7001 a Westman, E.u Rheumatology Unit, Department of Medicine, Karolinska Inst., Karolinska H., Stockholm, Sweden4 aut
7001 a Sunnerhagen, Mariau Linköpings universitet,Tekniska högskolan,Molekylär Bioteknik4 aut0 (Swepub:liu)marsu05
7001 a Hultenby, K.u Karolinska Institutet4 aut
7001 a Erlandsson, Harris H.u Karolinska Institutet4 aut
7102 a Karolinska Institutetb Rheumatology Unit, Department of Medicine, Karolinska Inst., Karolinska H., Stockholm, Sweden4 org
7730 t Journal of Autoimmunityd : Elsevier BVg 23:2, s. 95-102q 23:2<95-102x 0896-8411x 1095-9157
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-45639
8564 8u https://doi.org/10.1016/j.jaut.2004.05.002
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1961711

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