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Apoptotic neutrophi...
Apoptotic neutrophils containing Staphylococcus epidermidis stimulate macrophages to release the proinflammatory cytokines tumor necrosis factor-a and interleukin-6
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- Wilsson, Åsa (author)
- Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,Wilsson, Å., School of Health Sciences, Jönköping University, Jönköping, Sweden
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- Lind, Susanne (author)
- Linköpings universitet,Hälsouniversitetet,Omvårdnad
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- Öhman, Lena (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Infektionsmedicin,Infektionskliniken i Östergötland,Division of Medical Microbiology, Linköping University, Linköping, Sweden; and Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Nilsdotter-Augustinsson, Åsa (author)
- Östergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland,Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Lundqvist-Setterud, H. (author)
- Division of Medical Microbiology, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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- Lind, Sara (author)
- Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
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(creator_code:org_t)
- Oxford University Press, 2008
- 2008
- English.
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In: FEMS Immunology and Medical Microbiology. - : Oxford University Press. - 0928-8244 .- 1574-695X. ; 53:1, s. 126-135
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Staphylococcus epidermidis infections are usually nosocomial and involve colonization of biomaterials. The immune defense system cannot efficiently control the bacteria during these infections, which often results in protracted chronic inflammation, in which a key event is disturbed removal of neutrophils by tissue macrophages. While ingesting uninfected apoptotic neutrophils, macrophages release anti-inflammatory cytokines that lead to resolution of inflammation. In clinical studies, we have previously found elevated levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-a) and interleukin-6 in synovial fluid from prostheses infected with coagulase negative staphylococci. We show that macrophages phagocytosing apoptotic neutrophils containing S. epidermidis released TNF-a and interleukin-6, whereas macrophages phagocytosing spontaneously apoptotic neutrophils did not. This difference was not due to dissimilar phagocytic capacities, because macrophages ingested both types of neutrophils to the same extent. The activation was induced mainly by the apoptotic neutrophils themselves, not by the few remaining extracellular bacteria. Macrophages were not activated by apoptotic neutrophils that contained paraformaldehyde-killed S. epidermidis. Proinflammatory reactions induced by clearance of apoptotic neutrophils containing S. epidermidis might represent an important mechanism to combat the infective agent. This activation of macrophages may contribute to the development of chronic inflammation instead of inflammation resolution. © 2008 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Chronic inflammation
- Macrophage
- Neutrophil
- Phagocytosis
- Staphylococcus epidermidis infection
- TNF-a
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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