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Functional brown ad...
Functional brown adipose tissue in healthy adults.
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Virtanen, Kirsi A (author)
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- Lidell, Martin, 1970 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Orava, Janne (author)
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- Heglind, Mikael, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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- Westergren, Rickard, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Niemi, Tarja (author)
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Taittonen, Markku (author)
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Laine, Jukka (author)
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Savisto, Nina-Johanna (author)
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- Enerbäck, Sven, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
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Nuutila, Pirjo (author)
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: The New England journal of medicine. - 1533-4406. ; 360:15, s. 1518-25
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Abstract
Subject headings
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- Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
Keyword
- Adipocytes
- Brown
- metabolism
- Adipose Tissue
- Brown
- cytology
- metabolism
- Adiposity
- Adult
- Biopsy
- Cold Temperature
- Energy Metabolism
- Fluorodeoxyglucose F18
- diagnostic use
- pharmacokinetics
- Gene Expression
- Genetic Markers
- physiology
- Humans
- Ion Channels
- genetics
- metabolism
- Male
- Middle Aged
- Mitochondrial Proteins
- genetics
- metabolism
- Positron-Emission Tomography
- RNA
- Messenger
- metabolism
- Radiopharmaceuticals
- diagnostic use
- pharmacokinetics
- Up-Regulation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Virtanen, Kirsi ...
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Lidell, Martin, ...
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Orava, Janne
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Heglind, Mikael, ...
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Westergren, Rick ...
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Niemi, Tarja
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show more...
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Taittonen, Markk ...
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Laine, Jukka
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Savisto, Nina-Jo ...
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Enerbäck, Sven, ...
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Nuutila, Pirjo
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show less...
- Articles in the publication
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The New England ...
- By the university
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University of Gothenburg