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Functional brown adipose tissue in healthy adults.

Virtanen, Kirsi A (author)
Lidell, Martin, 1970 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
Orava, Janne (author)
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Heglind, Mikael, 1975 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
Westergren, Rickard, 1974 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
Niemi, Tarja (author)
Taittonen, Markku (author)
Laine, Jukka (author)
Savisto, Nina-Johanna (author)
Enerbäck, Sven, 1958 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik,Institute of Biomedicine, Department of Medical and Clinical Genetics
Nuutila, Pirjo (author)
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 (creator_code:org_t)
2009
2009
English.
In: The New England journal of medicine. - 1533-4406. ; 360:15, s. 1518-25
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.

Keyword

Adipocytes
Brown
metabolism
Adipose Tissue
Brown
cytology
metabolism
Adiposity
Adult
Biopsy
Cold Temperature
Energy Metabolism
Fluorodeoxyglucose F18
diagnostic use
pharmacokinetics
Gene Expression
Genetic Markers
physiology
Humans
Ion Channels
genetics
metabolism
Male
Middle Aged
Mitochondrial Proteins
genetics
metabolism
Positron-Emission Tomography
RNA
Messenger
metabolism
Radiopharmaceuticals
diagnostic use
pharmacokinetics
Up-Regulation

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art (subject category)

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