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Differences in inna...
Differences in innate immune function between allergic and nonallergic children: New insights into immune ontogeny
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- Tulic, Meri K (author)
- University of Western Australia
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- Hodder, Megan (author)
- Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet
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- McCarthy, Suzi (author)
- UWA
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- A Thornton, Catherine (author)
- Swansea University
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- Prescott, Susan L (author)
- University of Western Australia
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(creator_code:org_t)
- Elsevier Science B.V., Amsterdam, 2011
- 2011
- English.
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In: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. - : Elsevier Science B.V., Amsterdam. - 0091-6749. ; 127:2, s. 470-U1817
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Microbial products are of central interest in the modulation of allergic propensity. Objective: We sought to explore whether allergic children show differences in microbial Toll-like receptor (TLR)-mediated responses over their first 5 years of life. Methods: Mononuclear cells isolated from 35 allergic and 35 nonallergic children at birth and 1, 2.5, and 5 years of age were stimulated with TLR2-TLR9 ligands to study innate immune function and with allergens or mitogen to assess adaptive T-cell responses. Cytokine production was measured by using Luminex multiplexing technology. Results: Nonallergic children show progressive and significant age-related increases in innate cytokine responses (IL-1 beta, IL-6, TNF-alpha, and IL-10) to virtually all TLR ligands. This innate maturation corresponds with a parallel increase in adaptive T(H)1 (IFN-gamma) responses to allergens and mitogens. In contrast, allergic children show exaggerated innate responses at birth (P andlt; .01) but a relative decrease with age thereafter, so that by age 5 years, TLR responses are attenuated compared with those seen in nonallergic subjects (P andlt; .05). This early hyperresponsiveness in allergic subjects fails to translate to a corresponding maturation of T(H)1 function, which remains attenuated relative to that seen in nonallergic subjects but is associated with a characteristic age-dependent increase in allergen-specific T(H)2 responses (P andlt; .01). Conclusion: Our findings suggest significant differences in the developmental trajectory of innate immune function in children with allergic disease that might contribute to the recognized differences in postnatal adaptive T-cell immunity.
Keyword
- Toll-like receptor
- ontogeny
- innate immunity
- allergic disease
- children
- TECHNOLOGY
- TEKNIKVETENSKAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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