Artificial human corneas - Scaffolds for transplantation and host regeneration

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: id:"swepub:oai:DiVA.org:liu-70661" > Artificial human co...

1 of 1
Previous record
Next record
To hitlist

Artificial human corneas - Scaffolds for transplantation and host regeneration

Griffith, May (author): University of Ottawa Eye Institute, Ottawa, Ontario, Canada

Hakim, Malik (author): University of Ottawa Eye Institute, Ottawa, Ontario, Canada and National Research Council of Canada - ICPET, Ottawa, Ontario, Canada

Shimmura, Shigeto (author): Dental College, Ichikawa General Hospital Cornea Center, Ichikawa, Chiba, Japan

Watsky, Mitchell A. (author): Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee, USA

Li, Fengfu (author): University of Ottawa Eye Institute, Ottawa, Ontario, Canada and National Research Council of Canada - ICPET, Ottawa, Ontario, Canada

Carlsson, David (author): National Research Council of Canada - ICPET, Ottawa, Ontario, Canada

Doillon, Charles J. (author): Oncology and Molecular Endocrinology Research Center, Laval University, Quebec, Canada

Nakamura, Masatsugu (author): Santen Pharmaceutical Co. Ltd., Nara R&D Center, Ikoma-shi, Nara, Japan

Suuronen, Erik (author): University of Ottawa Eye Institute, Ottawa, Ontario, Canada

Shinozaki, Naoshi (author): Dental College, Ichikawa General Hospital Cornea Center, Ichikawa, Chiba, Japan

Nakata, Katsuhiko (author): Santen Pharmaceutical Co. Ltd., Nara R&D Center, Ikoma-shi, Nara, Japan

Sheardown, Heather (author): Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada

show less...

(creator_code:org_t)

Lippincott, Williams andamp; Wilkins, 2002
2002
English.
In: Cornea. - : Lippincott, Williams andamp; Wilkins. - 0277-3740 .- 1536-4798. ; 21:7, s. S54-S61

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Purpose. To review the development of artificial corneas (prostheses and tissue equivalents) for transplantation, and to provide recent updates on our tissue-engineered replacement corneas. Methods. Modified natural polymers and synthetic polymers were screened for their potential to replace damaged portions of the human cornea or the entire corneal thickness. These polymers, combined with cells derived from each of the three main corneal layers or stem cells, were used to develop artificial corneas. Functional testing was performed in vitro. Trials of biocompatibility and immune and inflammatory reactions were performed by implanting the most promising polymers into rabbit corneas. Results. Collagen-based biopolymers, combined with synthetic crosslinkers or copolymers, formed effective scaffolds for developing prototype artificial corneas that could be used as tissue replacements in the future. We have previously developed an artificial cornea that mimicked key morphologic and functional properties of the human cornea. The addition of synthetic polymers increased its toughness as it retained transparency and low light scattering, making the matrix scaffold more suitable for transplantation. These new composites were implanted into rabbits without causing any acute inflammation or immune response. We have also fabricated full-thickness composites that can be fully sutured. However, the long-term effects of these artificial corneas need to be evaluated. Conclusions. Novel tissue-engineered corneas that comprise composites of natural and synthetic biopolymers together with corneal cell lines or stem cells will, in the future, replace portions of the cornea that are damaged. Our results provide a basis for the development of both implantable temporary and permanent corneal replacements.

Keyword

artificial corneas; keratoprostheses; polymers; tissue engineering; tissue equivalents; transplantation
TECHNOLOGY
TEKNIKVETENSKAP

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Cornea (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Griffith, May; Hakim, Malik; Shimmura, Shiget ...; Watsky, Mitchell ...; Li, Fengfu; Carlsson, David; show more...; Doillon, Charles ...; Nakamura, Masats ...; Suuronen, Erik; Shinozaki, Naosh ...; Nakata, Katsuhik ...; Sheardown, Heath ...; show less...

Articles in the publication: Cornea

By the university: Linköping University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se