id:"swepub:oai:DiVA.org:liu-73744"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02895naa a2200325 4500 | |
| 001 | oai:DiVA.org:liu-73744 | |
| 003 | SwePub | |
| 008 | 120112s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-737442 URI |
| 024 | 7 | a https://doi.org/10.5301/JBM.2011.85502 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Shen, Yang-meiu Linköpings universitet,Hälsouniversitetet,Onkologi4 aut0 (Swepub:liu)yansh76 |
| 245 | 1 0 | a Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis |
| 264 | 1 | b Wichtig Editore,c 2011 |
| 338 | a print2 rdacarrier | |
| 520 | a Background: To investigate the expression of glucose transporter 1 (GLUT1) in colorectal cancer (CRC) and its relationship to clinicopathological variables. Methods: The expression of GLUT1 in 163 primary tumors together with the corresponding normal mucosa, and 36 liver metastases was examined using real-time PCR. Results: The mean value of GLUT1 was higher in primary tumors (50.390 +/- 68.648) than in the corresponding normal mucosa (20.437 +/- 28.703, p less than 0.0001), while there was no significant difference in GLUT1 expression between CRC and liver metastasis (50.390 +/- 68.648 vs 52.277 +/- 52.482, p = 0.190). In CRCs, GLUT1 expression was higher in poorly differentiated than in well and moderately differentiated tumors (p = 0.022), and higher in stage III + IV than in stage I + II tumors (p = 0.035). The patients with high-expressed GLUT1 had a worse prognosis than those with low-expressed GLUT1 independently of gender, age, tumor site, stage and differentiation (p = 0.026, RR 2.737, 95% CI 1.126-6.651) in stage I-III CRCs. In liver metastasis, GLUT1 expression was higher in larger tumors than in smaller ones (p = 0.025). Conclusions: Overexpression of GLUT1 in stage I-III CRCs was independently associated with poor prognosis. | |
| 653 | a GLUT1; Colorectal cancer; Prognosis; Real-time PCR | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Arbman, Gunnaru Östergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Kirurgiska kliniken i Östergötland4 aut0 (Swepub:liu)gunar63 |
| 700 | 1 | a Olsson, Birgitu Linköpings universitet,Onkologi,Hälsouniversitetet4 aut0 (Swepub:liu)birol93 |
| 700 | 1 | a Sun, Xiao-Fengu Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US4 aut0 (Swepub:liu)xiasu45 |
| 710 | 2 | a Linköpings universitetb Hälsouniversitetet4 org |
| 773 | 0 | t International Journal of Biological Markersd : Wichtig Editoreg 26:3, s. 166-172q 26:3<166-172x 0393-6155x 1724-6008 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73744 |
| 856 | 4 8 | u https://doi.org/10.5301/JBM.2011.8550 |
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