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Elderly men with a history of distal radius fracture have significantly lower calcaneal bone density and free androgen index than age-matched controls
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- Risto, Olof (author)
- Östergötlands Läns Landsting,Linköpings universitet,Ortopedi och idrottsmedicin,Hälsouniversitetet,Ortopedkliniken i Linköping
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- Hammar, Ewa (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- Hammar, Karl (author)
- Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet
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- (creator_code:org_t)
- 2012-02-04
- 2012
- English.
- In: The Aging Male. - : Informa Healthcare. - 1368-5538 .- 1473-0790. ; 15:1, s. 59-62
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: Age related bone loss is widely accepted as related to decreased serum levels of circulating sex hormones. Epidemiological data also show distal radius fractures in men to be a sensitive marker of bone fragility. The aim of this study was to assess if men with a history of distal radius fracture have lower bone mass density (BMD), lower free androgen index (FAI), lower total testosterone (T) and lower bio-available testosterone (Bio-T) than healthy age-matched controls. Patients and methods: A case-control study is based on consecutive cases treated for low energy distal radius fracture at our department and age-matched controls. Thirty-nine men treated between 1997-2004 and 45 age-matched controls underwent calcaneal bone density measurements (t-score) and analyses of T, Bio-T and serum hormone binding globulin (SHBG). Results: The fracture group had lower BMD (p andlt; 0.01) and lower FAI (p = 0.01). Linear regression analysis showed a correlation between Bio-T and t-scores (p = 0.03). Using analysis of covariance, a significant difference with lower Bio-T in the fracture group was shown. Conclusion: Bio-T seems to correlate with BMD in elderly men and may serve as a marker for increased fracture risk in this patient group.
Keyword
- Bone mineral density
- male
- fractures
- osteoporosis
- testosterone
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Risto, Olof
- Hammar, Ewa
- Hammar, Karl
- Fredrikson, Mats
- Hammar, Mats
- Wahlström, Ola
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- The Aging Male
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- Linköping University
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