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In vitro susceptibi...
In vitro susceptibility of CTX-M-producing Escherichia coli to non-beta-lactam agents
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- Östholm Balkhed, Åse (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
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- Tärnberg, Maria (author)
- Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
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- Monstein, Hans-Jurg (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
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- Hällgren, Anita (author)
- Östergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland
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- Hanberger, Håkan (author)
- Östergötlands Läns Landsting,Linköpings universitet,Infektionsmedicin,Hälsouniversitetet,Infektionskliniken i Östergötland
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- Nilsson, Lennart E (author)
- Linköpings universitet,Klinisk mikrobiologi,Hälsouniversitetet
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Background: The objective of this study was to investigate the in vitro activity of different antibiotics against CTX-M-producing Escherichia coli, to determine the occurrence of multiresistance and plasmid mediated quinolone resistance among these isolates. Methods: A total of 198 isolates of E. coli with ESBL phenotype and mainly CTX-M genotype, were studied. The MICs for amikacin, chloramphenicol, ciprofloxacin, colistin, fosfomycin, gentamicin, nalidixic acid, nitrofurantoin, tigecycline, tobramycin, trimethoprim and trimethoprim-sulphamethoxazole were determined with the Etest. Susceptibility was defined according to the breakpoints of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). MIC(50) and MIC(90) values were calculated. Results: ≥95% of isolates were susceptible to amikacin, nitrofurantoin, colistin, tigecyclin, and fosfomycin. CTX-M group 9 was more susceptible than CTX-M group 1 to ciprofloxacin, gentamicin, and tobramycin. 68% of the isolates were multiresistant, and the most common multi-resistance pattern was ESBL-phenotype with decreased susceptibility to trimethoprim, trimethoprim-sulphamethoxazol, ciprofloxacin, gentamicin and tobramycin. Only one isolate carried a qnrS1-gene, nine isolates carried aac(6’)-Ib-cr. Conclusions: The high frequency of multi-resistance found in this study is alarming and it is urgent to find strategies to limit the emergence and spread of these multi-resistant strains.
Keyword
- Etest
- MIC
- ESBL
- MEDICINE
- MEDICIN
Publication and Content Type
- vet (subject category)
- ovr (subject category)
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