Extensive Intimal Apolipoprotein A1-Derived Amyloid Deposits in a Patient with an Apolipoprotein A1 Mutation

Amarzguioui, Mohammed (author): The Biotechnology Centre of Oslo, University of Oslo, Gaustadalleen 21, Oslo, Norway

Mucchiano, Gerd (author): Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet

Häggqvist, Bo (author): Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet

Westermark, Bo (author): Linköpings universitet,Molekylär och immunologisk patologi,Hälsouniversitetet

Kavlie, Anita (author): The Biotechnology Centre of Oslo, University of Oslo, Gaustadalleen 21, Oslo, Norway

Sletten, Knut (author): The Biotechnology Centre of Oslo, University of Oslo, Gaustadalleen 21, Oslo, Norway

Prydz, Hans (author): The Biotechnology Centre of Oslo, University of Oslo, Gaustadalleen 21, Oslo, Norway

(creator_code:org_t)

Elsevier BV, 1998
1998
English.
In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 242:3, s. 534-539

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

In the aortic intima amyloid deposits are often associated with atherosclerotic plaques. In a recent study of one patient with aortic intimal amyloid the major fibril protein was an N-terminal fragment of apolipoprotein A1 (apoA1) consisting of 69 amino acid residues. In the present study, we have screened the apoA1 gene for mutations in autopsy cases with aortic intimal amyloid immunohistochemically positive for apoA1, using single stranded conformational polymorphism (SSCP) analysis and DNA sequencing. All cases except one had a normal apoA1 gene sequence. One case of exceptionally severe atherosclerosis combined with extensive intimal amyloid deposits showed an apoA1 deletion corresponding to Lys 107. Thus, wild type apoA1 is amyloidogenic but our findings suggest that the expression of a mutant apoA1-form may be associated with enhanced amyloidogenicity.

By the author/editor: Amarzguioui, Moh ...; Mucchiano, Gerd; Häggqvist, Bo; Westermark, Bo; Kavlie, Anita; Sletten, Knut; show more...; Prydz, Hans; show less...

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