id:"swepub:oai:DiVA.org:liu-79798"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04424naa a2200433 4500 | |
| 001 | oai:DiVA.org:liu-79798 | |
| 003 | SwePub | |
| 008 | 120814s2012 | |||||||||||000 ||eng| | |
| 009 | oai:gup.ub.gu.se/160363 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-797982 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00390162 DOI |
| 024 | 7 | a https://gup.ub.gu.se/publication/1603632 URI |
| 040 | a (SwePub)liud (SwePub)gu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Zhao, Yelinu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut |
| 245 | 1 0 | a Combined Multivariate and Pathway Analyses Show That Allergen-Induced Gene Expression Changes in CD4(+) T Cells Are Reversed by Glucocorticoids |
| 264 | c 2012-06-12 | |
| 264 | 1 | b Public Library of Science,c 2012 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Glucocorticoids (GCs) play a key role in the treatment of allergy. However, the genome-wide effects of GCs on gene expression in allergen-challenged CD4(+) T cells have not been described. The aim of this study was to perform a genome-wide analysis to investigate whether allergen-induced gene expression changes in CD4(+) T cells could be reversed by GCs. Methodology/Principal Findings: Gene expression microarray analysis was performed to profile gene expression in diluent( D), allergen- (A), and allergen + hydrocortisone- (T) challenged CD4(+) T cells from patients with seasonal allergic rhinitis. Principal component analysis (PCA) showed good separation of the three groups. To identify the correlation between changes in gene expression in allergen-challenged CD4(+) T cells before and after GC treatment, we performed orthogonal partial least squares discriminant analysis (OPLS-DA) followed by Pearson correlation analysis. This revealed that allergen-induced genes were widely reversed by GC treatment (r = -0.77, Pless than0.0001). We extracted 547 genes reversed by GC treatment from OPLS-DA models based on their high contribution to the discrimination and found that those genes belonged to several different inflammatory pathways including TNFR2 Signalling, Interferon Signalling, Glucocorticoid Receptor Signalling and T Helper Cell Differentiation. The results were supported by gene expression microarray analyses of two independent materials. Conclusions/Significance: Allergen-induced gene expression changes in CD4(+) T cells were reversed by treatment with glucocorticoids. The top allergen-induced genes that reversed by GC treatment belonged to several inflammatory pathways and genes of known or potential relevance for allergy. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Pediatrik0 (SwePub)302212 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Pediatrics0 (SwePub)302212 hsv//eng |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Wang, Huiu Gothenburg University,Göteborgs universitet,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics4 aut0 (Swepub:gu)xwanhu |
| 700 | 1 | a Gustafsson, Mikau Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:liu)mikgu75 |
| 700 | 1 | a Muraro, Antonellau University of Padua, Italy4 aut |
| 700 | 1 | a Bruhn, Sörenu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:liu)sorbr27 |
| 700 | 1 | a Benson, Mikaelu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Hälsouniversitetet4 aut0 (Swepub:gu)xbenmi |
| 710 | 2 | a Linköpings universitetb Institutionen för klinisk och experimentell medicin4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Scienceg 7:6q 7:6x 1932-6203 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:544985/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0039016&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-79798 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0039016 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/160363 |
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