id:"swepub:oai:DiVA.org:liu-80201"
Sökning: id:"swepub:oai:DiVA.org:liu-80201" > A Novel Class of An...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03872naa a2200445 4500 | |
| 001 | oai:DiVA.org:liu-80201 | |
| 003 | SwePub | |
| 008 | 120822s2012 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:125066740 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-802012 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00412352 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1250667402 URI |
| 040 | a (SwePub)liud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Chang, Chien-Hsingu Morris Plains, New Jersey, United States of America4 aut |
| 245 | 1 0 | a A Novel Class of Anti-HIV Agents with Multiple Copies of Enfuvirtide Enhances Inhibition of Viral Replication and Cellular Transmission In Vitro |
| 264 | c 2012-07-23 | |
| 264 | 1 | b Public Library of Science (PLoS),c 2012 |
| 338 | a electronic2 rdacarrier | |
| 520 | a We constructed novel HIV-1 fusion inhibitors that may overcome the current limitations of enfuvirtide, the first such therapeutic in this class. The three prototypes generated by the Dock-and-Lock (DNL) technology to comprise four copies of enfuvirtide tethered site-specifically to the Fc end of different humanized monoclonal antibodies potently neutralize primary isolates (both R5-tropic and X4-tropic), as well as T-cell-adapted strains of HIV-1 in vitro. All three prototypes show EC50 values in the subnanomolar range, which are 10- to 100-fold lower than enfuvirtide and attainable whether or not the constitutive antibody targets HIV-1. The potential of such conjugates to purge latently infected cells was also demonstrated in a cell-to-cell viral inhibition assay by measuring their efficacy to inhibit the spread of HIV-1LAI from infected human peripheral blood mononuclear cells to Jurkat T cells over a period of 30 days following viral activation with 100 nM SAHA (suberoylanilide hydroxamic acid). The IgG-like half-life was not significantly different from that of the parental antibody, as shown by the mean serum concentration of one prototype in mice at 72 h. These encouraging results provide a rationale to develop further novel anti-HIV agents by coupling additional antibodies of interest with alternative HIV-inhibitors via recombinantly-produced, self-assembling, modules. | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 700 | 1 | a Hinkula, Jormau Linköpings universitet,Molekylär virologi,Hälsouniversitetet4 aut0 (Swepub:liu)jorhi40 |
| 700 | 1 | a Loo, Meiyuu Morris Plains, New Jersey, United States of America4 aut |
| 700 | 1 | a Falkeborn, Tinau Linköpings universitet,Molekylär virologi,Hälsouniversitetet4 aut0 (Swepub:liu)tinlu81 |
| 700 | 1 | a Li, Rongxiuu Morris Plains, New Jersey, United States of America4 aut |
| 700 | 1 | a Cardillo, Thomas M.u Morris Plains, New Jersey, United States of America4 aut |
| 700 | 1 | a Rossi, Edmund A.u Morris Plains, New Jersey, United States of America4 aut |
| 700 | 1 | a Goldenberg, David M.u Morris Plains, New Jersey, United States of America4 aut |
| 700 | 1 | a Wahren, Brittau Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden4 aut |
| 710 | 2 | a Morris Plains, New Jersey, United States of Americab Molekylär virologi4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Science (PLoS)g 7:7, s. e41235-e41235q 7:7<e41235-e41235x 1932-6203 |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:546144/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0041235&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-80201 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0041235 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:125066740 |
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