Laser-induced fluorescence studies of the biodistribution of carotenoporphyrins in mice

Nilsson, Henrik (author): Lund University Medical Laser Center, Lund Institute of Technology, Lund, Sweden

Johansson, Jonas (author): Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Lund University Medical Laser Center and Department of Physics, Lund Institute of Technology, Lund, Sweden

Svanberg, Katarina (author): Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Lund University Medical Laser Center, Lund Institute of Technology and the Department of Oncology, Lund University Hospital, Lund, Sweden

Svanberg, Sune (author): Lund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Lund University Medical Laser Center and Department of Physics, Lund Institute of Technology, Lund, Sweden

Segalla, A. (author): Department of Biology, Padova University, Padova, Italy

Gust, D. (author): Department of Chemistry and Biochemistry, Center for the Study of Early Events in Photosynthesis, Arizona State University, USA

Moore, A. L. (author): Department of Chemistry and Biochemistry, Center for the Study of Early Events in Photosynthesis, Arizona State University, USA

Moore, T. A. (author): Department of Chemistry and Biochemistry, Center for the Study of Early Events in Photosynthesis, Arizona State University, USA

(creator_code:org_t)

Springer Science and Business Media LLC, 1997
1997
English.
In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 76:3, s. 355-364

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Abstract Subject headings

The biodistribution of two recently developed tumour markers, trimethylated (CP(Me)3) and trimethoxylated (CP(OMe)3) carotenoporphyrin, was investigated by means of laser-induced fluorescence (LIF) after i.v. injection into 38 tumour-bearing (MS-2 fibrosarcoma) female Balb/c mice. At 3, 24, 48 or 96 h after administration, the carotenoporphyrin fluorescence was measured in tumoral and peritumoral tissue, as well as in the abdominal, thoracic and cranial cavities. The fluorescence was induced by a nitrogen laser-pumped dye laser, emitting light at 425 nm, and analysed by a polychromator equipped with an image-intensified CCD camera. The fluorescence was evaluated at 490, 655 and 720 nm: the second and third wavelengths represent the carotenoporphyrin (CP)-related peaks, whereas the first one is close to the peak of the tissue autofluorescence. The tumour and the liver were the two tissue types showing the strongest carotenoporphyrin-related fluorescence, whereas the cerebral cortex and muscle consistently exhibited weak substance-related fluorescence. In most tissue types, the fluorescence intensities decreased over time. A few exceptions were observed, notably the liver, in which the intensity remained remarkably constant over the time period investigated.

By the author/editor: Nilsson, Henrik; Johansson, Jonas; Svanberg, Katari ...; Svanberg, Sune; Jori, G.; Reddi, E.; show more...; Segalla, A.; Gust, D.; Moore, A. L.; Moore, T. A.; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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