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FältnamnIndikatorerMetadata
00005921naa a2200409 4500
001oai:DiVA.org:liu-85339
003SwePub
008121118s2012 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-853392 URI
0247 a https://doi.org/10.1118/1.47472642 DOI
040 a (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Beaulieu, Lucu Centre hospitalier universitaire de Québec, Canada and Université Laval, Québec, Canada4 aut
2451 0a Report of the Task Group 186 on model-based dose calculation methods in brachytherapy beyond the TG-43 formalism :b Current status and recommendations for clinical implementation
264 c 2012-09-25
264 1b American Association of Physicists in Medicine,c 2012
338 a print2 rdacarrier
520 a The charge of Task Group 186 (TG-186) is to provide guidance for early adopters of model-based dose calculation algorithms (MBDCAs) for brachytherapy (BT) dose calculations to ensure practice uniformity. Contrary to external beam radiotherapy, heterogeneity correction algorithms have only recently been made available to the BT community. Yet, BT dose calculation accuracy is highly dependent on scatter conditions and photoelectric effect cross-sections relative to water. In specific situations, differences between the current water-based BT dose calculation formalism (TG-43) and MBDCAs can lead to differences in calculated doses exceeding a factor of 10. MBDCAs raise three major issues that are not addressed by current guidance documents: (1) MBDCA calculated doses are sensitive to the dose specification medium, resulting in energy-dependent differences between dose calculated to water in a homogeneous water geometry (TG-43), dose calculated to the local medium in the heterogeneous medium, and the intermediate scenario of dose calculated to a small volume of water in the heterogeneous medium. (2) MBDCA doses are sensitive to voxel-by-voxel interaction cross sections. Neither conventional single-energy CT nor ICRU∕ICRP tissue composition compilations provide useful guidance for the task of assigning interaction cross sections to each voxel. (3) Since each patient-source-applicator combination is unique, having reference data for each possible combination to benchmark MBDCAs is an impractical strategy. Hence, a new commissioning process is required. TG-186 addresses in detail the above issues through the literature review and provides explicit recommendations based on the current state of knowledge. TG-43-based dose prescription and dose calculation remain in effect, with MBDCA dose reporting performed in parallel when available. In using MBDCAs, it is recommended that the radiation transport should be performed in the heterogeneous medium and, at minimum, the dose to the local medium be reported along with the TG-43 calculated doses. Assignments of voxel-by-voxel cross sections represent a particular challenge. Electron density information is readily extracted from CT imaging, but cannot be used to distinguish between different materials having the same density. Therefore, a recommendation is made to use a number of standardized materials to maintain uniformity across institutions. Sensitivity analysis shows that this recommendation offers increased accuracy over TG-43. MBDCA commissioning will share commonalities with current TG-43-based systems, but in addition there will be algorithm-specific tasks. Two levels of commissioning are recommended: reproducing TG-43 dose parameters and testing the advanced capabilities of MBDCAs. For validation of heterogeneity and scatter conditions, MBDCAs should mimic the 3D dose distributions from reference virtual geometries. Potential changes in BT dose prescriptions and MBDCA limitations are discussed. When data required for full MBDCA implementation are insufficient, interim recommendations are made and potential areas of research are identified. Application of TG-186 guidance should retain practice uniformity in transitioning from the TG-43 to the MBDCA approach.
650 7a NATURVETENSKAPx Fysikx Annan fysik0 (SwePub)103992 hsv//swe
650 7a NATURAL SCIENCESx Physical Sciencesx Other Physics Topics0 (SwePub)103992 hsv//eng
7001 a Carlsson Tedgren, Åsau Linköpings universitet,Medicinsk radiofysik,Hälsouniversitetet4 aut0 (Swepub:liu)asaca90
7001 a Carrier, Jean-Françoisu Centre hospitalier de l’Université de Montréal, Québec, Canada and Département de physique, Université de Montréal, Québec Canada4 aut
7001 a Davis, Stephen D.u University of Wisconsin-Madison, USA and McGill University Health Centre, Montréal, Québec, Canada4 aut
7001 a Mourtada, Firasu Helen F. Graham Cancer Center, Christiana Care Health System, Newark, Delaware, USA4 aut
7001 a Rivard, Mark J.u Tufts University School of Medicine, Boston, Massachusetts, USA4 aut
7001 a Thomson, Rowan M.u Carleton University, Ottawa, Ontario, Canada4 aut
7001 a Verhaegen, Franku Maastricht University Medical Center, the Netherlands and McGill University Health Centre, Montréal, Québec, Canada4 aut
7001 a Wareing, Todd A.u Transpire Inc., Gig Harbor, Washington, USA4 aut
7001 a Williamson, Jeffrey F.u Virginia Commonwealth University, Richmond, USA4 aut
7102 a Centre hospitalier universitaire de Québec, Canada and Université Laval, Québec, Canadab Medicinsk radiofysik4 org
7730 t Medical physics (Lancaster)d : American Association of Physicists in Medicineg 39:10, s. 6208-6236q 39:10<6208-6236x 0094-2405
8564 u https://aapm.onlinelibrary.wiley.com/doi/pdfdirect/10.1118/1.4747264
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85339
8564 8u https://doi.org/10.1118/1.4747264

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