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Redox events in HTL...
Redox events in HTLV-1 tax-induced apoptotic T-cell death
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- Chlichlia, K. (författare)
- Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany
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- Los, Marek Jan (författare)
- Department of Immunology and Cell Biology, University of Muenster, Roentgenstr. 21, D-48149 Muenster, Germany
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- Schulze-Osthoff, Klaus (författare)
- Department of Immunology and Cell Biology, University of Muenster, Roentgenstr. 21, D-48149 Muenster, Germany
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- Gazzolo, L. (författare)
- INSERM U412, Ecole Normale S périeure de Lyon, 69367 Lyon, Cedex 07, France
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- Schirrmacher, V. (författare)
- Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany
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- Khazaie, K. (författare)
- Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany; 4Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, U.S.A.
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Division of Cellular Immunology (G0100), Tumor Immunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, D69120 Heidelberg, Germany Department of Immunology and Cell Biology, University of Muenster, Roentgenstr 21, D-48149 Muenster, Germany (creator_code:org_t)
- Mary Ann Liebert, Inc. publishers, 2002
- 2002
- Engelska.
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Ingår i: Antioxidants and Redox Signaling. - : Mary Ann Liebert, Inc. publishers. - 1523-0864 .- 1557-7716. ; 4:3, s. 471-477
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http://liu.diva-port...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- A number of studies implicate reactive oxygen intermediates in the induction of DNA damage and apoptosis. Recent studies suggest that the human T-cell leukemia virus type I (HTLV-1) Tax protein induces oxidative stress and apoptotic T-cell death. Activation of the T-cell receptor/CD3 pathway enhances the Tax-mediated oxidative and apoptotic effects. Tax-mediated apoptosis and oxidative stress as well as activation of nuclear factor-kappaB can be potently suppressed by antioxidants. This review focuses on Tax-dependent changes in the intracellular redox status and their role in Tax-mediated DNA damage and apoptosis. The relevance of these observations to HTLV-1 virus-mediated T-cell transformation and leukemogenesis are discussed.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- dna-repair
- gene-expression
- human thioredoxin
- leukemia-virus
- nf-kappa-b
- oxidative stress
- prooxidant state
- Signaling pathway
- transcription factors
- virus type-i
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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