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An Fcγ receptor I (CD64)-negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen-activated CD4-positive cytotoxic T cells
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- Grage-Griebenow, E. (author)
- Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
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- Baran, J. (author)
- Jagiellonian University, Institute of Molecular Biology, Cracow, Poland
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- Loppnow, H. (author)
- Forschungszentrum Borstel, Department of Immunology and Cell Biology, Borstel, Germany
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- Wiley, 1997
- 1997
- English.
- In: European Journal of Immunology. - : Wiley. - 0014-2980 .- 1521-4141. ; 27:9, s. 2358-2365
- Journal article (peer-reviewed)
Abstract
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- It has been demonstrated that in monocyte/T cell co-cultures activated with recall antigens, cytotoxic T cells were generated which are able to reduce the number of antigen-presenting monocytes. In previous studies we could show that a minor subset of monocytes, the Fc gamma receptor I-negative (CD64(-)) monocytes, exhibits significantly higher antigen-presenting capacity than the main population of monocytes (> 90%) which are Fc gamma receptor I-positive (CD64(+)). Therefore, we addressed the question whether they are also differentially susceptible to T cell-mediated killing. In the present study we demonstrate that the CD64(-) monocyte subset is more resistant to killing by antigen-activated T cells than CD64(+) monocytes, as indicated by a higher viability and recovery of CD64(-) monocytes. This mechanism involves CD95 (Fas) antigen, since monocyte death in co-cultures with antigen-activated T cells could be partially reduced by blocking anti-Fas monoclonal antibodies (mAb). In agreement with this finding, although CD95 antigen was expressed on CD64(+) and CD64(-) monocytes at comparable levels, killing of CD64(-) monocytes by activating anti-Fas mAb was lower than of CD64(+) monocytes.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Apoptosis
- CD64-negative monocytes
- cytotoxic T cell
- dendritic cells
- differential expression
- enzyme-like protease
- fas-mediated apoptosis
- flow-cytometry
- ifn-alpha
- lymphocytes
- macrophages
- monoclonal-antibodies
- presenting cells
- recall antigen
- resistance to killing
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- ref (subject category)
- art (subject category)
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- Los, Marek Jan
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- Pryjma, J.
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