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Time to secondary p...
Time to secondary progression in patients with multiple sclerosis who were treated with first generation immunomodulating drugs
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- Tedeholm, Helen, 1978 (author)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
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- Lycke, Jan, 1956 (author)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
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- Skoog, Bengt (author)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
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- Lisovskaja, Vera, 1984 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden
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- Hillert, J (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Dahle, Charlotte (author)
- Östergötlands Läns Landsting,Linköpings universitet,Klinisk immunologi,Hälsouniversitetet,Klinisk immunologi och transfusionsmedicin,Linköping University
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- Fagius, Jan (author)
- Uppsala universitet,Neurologi,Karolinska University Hospital, Sweden
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- Fredrikson, S (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Landtblom, Anne-Marie (author)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Linköping University
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- Malmeström, Clas, 1965 (author)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
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- Martin, C (author)
- Karolinska Institutet,University Hospital, Sweden
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- Piehl, F (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Runmarker, B (author)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
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- Stawiarz, L (author)
- Karolinska Institutet,Karolinska University Hospital, Sweden
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- Vrethem, Magnus (author)
- Östergötlands Läns Landsting,Linköpings universitet,Neurologi,Hälsouniversitetet,Neurologiska kliniken,Linköping University
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- Nerman, Olle, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics,Chalmers, Sweden
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- Andersen, Oluf, 1941 (author)
- Sahlgrens University Hospital, Sweden,Göteborgs universitet,University of Gothenburg
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(creator_code:org_t)
- 2012-11-01
- 2013
- English.
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In: Multiple Sclerosis Journal. - : SAGE Publications (UK and US). - 1352-4585 .- 1477-0970. ; 19:6, s. 765-774
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Abstract
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- Background: It is currently unknown whether early immunomodulatory treatment in relapsing-remitting MS (RRMS) can delay the transition to secondary progression (SP). less thanbrgreater than less thanbrgreater thanObjective: To compare the time interval from onset to SP in patients with RRMS between a contemporary cohort, treated with first generation disease modifying drugs (DMDs), and a historical control cohort. less thanbrgreater than less thanbrgreater thanMethods: We included a cohort of contemporary RRMS patients treated with DMDs, obtained from the Swedish National MS Registry (disease onset between 1995-2004, n = 730) and a historical population-based incidence cohort (onset 1950-64, n = 186). We retrospectively analyzed the difference in time to SP, termed the "period effect" within a 12-year survival analysis, using Kaplan-Meier and Cox regression analysis. less thanbrgreater than less thanbrgreater thanResults: We found that the "period" affected the entire severity spectrum. After adjusting for onset features, which were weaker in the contemporary material, as well as the therapy initiation time, the DMD-treated patients still exhibited a longer time to SP than the controls (hazard ratios: men, 0.32; women, 0.53). less thanbrgreater than less thanbrgreater thanConclusion: Our results showed there was a longer time to SP in the contemporary subjects given DMD. Our analyses suggested that this effect was not solely driven by the inclusion of benign cases, and it was at least partly due to the long-term immunomodulating therapy given.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Disease-modifying drugs
- disease progression
- disease severity
- epidemiology
- multiple sclerosis
- relapsing-remitting multiple sclerosis
- secondary progressive multiple sclerosis
- Sweden
- time to progression
- MEDICINE
- MEDICIN
- Neurology
- multipel skleros
- DMD
- progression
- RRMS
- SPMS
- bromsmedicin
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Tedeholm, Helen, ...
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Lycke, Jan, 1956
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Skoog, Bengt
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Lisovskaja, Vera ...
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Hillert, J
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Dahle, Charlotte
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show more...
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Fagius, Jan
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Fredrikson, S
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Landtblom, Anne- ...
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Malmeström, Clas ...
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Martin, C
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Piehl, F
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Runmarker, B
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Stawiarz, L
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Vrethem, Magnus
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Nerman, Olle, 19 ...
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Andersen, Oluf, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Multiple Scleros ...
- By the university
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Linköping University
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Chalmers University of Technology
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Karolinska Institutet
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Uppsala University
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University of Gothenburg