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Serum thymidine kin...
Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial
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- Bjohle, J (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Bergqvist, J (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Gronowitz, J. Simon (author)
- Uppsala universitet,Klinisk virologi,Biov Int AB, Sweden
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- Johansson, H (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Carlsson, L (author)
- Sundsvall Gen Hospital, Sweden
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- Einbeigi, Z (author)
- Sahlgrens University Hospital, Sweden
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- Linderholm, B (author)
- Karolinska Institutet,Sahlgrens University Hospital, Sweden
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- Loman, Niklas (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University, Sweden
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- Malmberg, M (author)
- Helsingborg Gen Hospital, Sweden,Lund University, Sweden,Kalmar Gen Hospital, Sweden
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- Soderberg, M (author)
- Lund University, Sweden
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- Sundquist, M (author)
- Kalmar Gen Hospital, Sweden
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- Walz, Thomas (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Onkologiska kliniken US,Karolinska Institute, Sweden
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- Fernö, Mårten (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Bergh, J (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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- Hatschek, T (author)
- Karolinska Institutet,Karolinska Institute, Sweden
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(creator_code:org_t)
- 2013-06-05
- 2013
- English.
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In: Breast Cancer Research and Treatment. - : Springer Verlag (Germany). - 0167-6806 .- 1573-7217. ; 139:3, s. 751-758
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The primary objective was to estimate serum thymidine kinase 1 (TK1) activity, reflecting total body cell proliferation rate including cancer cell proliferation, in women with loco regional inoperable or metastatic breast cancer participating in a prospective and randomized study. Secondary objectives were to analyze TK1 in relation to progression-free survival (PFS), overall survival (OS), therapy response and other tumour characteristics, including CA 15-3, widely used as a standard serum marker for disease progression. TK1 and CA 15-3 were analysed in 198 serum samples collected prospectively from women included in the randomized TEX trial between December 2002 and June 2007. TK1 activity was determined by the ELISA based DiviTum (TM) assay, and CA 15-3 analyses was generated with the electrochemiluminescence immunoassay Cobas Elecsys CA 15-3 II. High pre-treatment TK1 activity predicted shorter PFS (10 vs. 15 months p = 0.02) and OS (21 vs. 38 months, p andlt; 0.0001), respectively. After adjustment for age, metastatic site and study treatment TK1 showed a trend as predictor of PFS (p = 0.059) and was an independent prognostic factor for OS, (HR 1.81, 95 % confidence interval (CI) 1.26-2.61, p = 0.001). There was a trend of shortened OS for women with high CA 15-3 (p = 0.054) in univariate analysis, but not after adjustment for the above mentioned covariates. Both TK1 (p = 0.0011) and CA 15-3 (p = 0.0004) predicted response to treatment. There were statistically different distributions of TK1 and CA 15-3 in relation to the site of metastases. TK1 activity measured by DiviTum (TM) predicted therapy response, PFS and OS in loco regional inoperable or disseminated breast cancer. These results suggest that this factor is a useful serum marker. In the present material, a prognostic value of CA 15-3 could not be proven.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- TK1
- CA 15-3
- Breast cancer
- Prognostic factor
- Predictive factor
- DiviTum
- MEDICINE
- MEDICIN
- TK1
- CA 15-3
- Breast cancer
- Prognostic factor
- Predictive factor
- DiviTum
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Bjohle, J
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Bergqvist, J
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Gronowitz, J. Si ...
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Johansson, H
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Carlsson, L
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Einbeigi, Z
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show more...
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Linderholm, B
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Loman, Niklas
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Malmberg, M
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Soderberg, M
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Sundquist, M
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Walz, Thomas
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Fernö, Mårten
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Bergh, J
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Hatschek, T
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Breast Cancer Re ...
- By the university
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Linköping University
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Lund University
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Karolinska Institutet
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Uppsala University