Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors

Spasokukotskaja, T. (author): Semmelweis University Medical School, Budapest, Hungary

Spyrou, Giannis (author): Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden

(creator_code:org_t)

Elsevier, 1988
1988
English.
In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier. - 0006-291X .- 1090-2104. ; 155:2, s. 923-929

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Abstract Subject headings

Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into dCDP-choline and dCDP-ethanolamine beside the well-known pathway i.e. incorporation into DNA in form of dCMP and dTMP. Hydroxyurea increased the labeling of the deoxyliponucleotides from 5-3H-deoxycytidine in spite of its inhibition of DNA synthesis.

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