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Deoxycytidine is sa...
Deoxycytidine is salvaged not only into DNA but also into phospholipid precursors
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- Spasokukotskaja, T. (author)
- Semmelweis University Medical School, Budapest, Hungary
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- Spyrou, Giannis (author)
- Medical Nobel Institute, Karolinska Institute, Stockholm, Sweden
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- Staub, M. (author)
- Semmelweis University Medical School, Budapest, Hungary
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(creator_code:org_t)
- Elsevier, 1988
- 1988
- English.
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In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier. - 0006-291X .- 1090-2104. ; 155:2, s. 923-929
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Abstract
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- Deoxycytidine metabolism was investigated in light density human tonsillar lymphocytes using 5-3H-deoxycytidine as extracellular precursor. A significant portion of the deoxycytidine (more than 50% of ethanol soluble pool) was found to incorporate into dCDP-choline and dCDP-ethanolamine beside the well-known pathway i.e. incorporation into DNA in form of dCMP and dTMP. Hydroxyurea increased the labeling of the deoxyliponucleotides from 5-3H-deoxycytidine in spite of its inhibition of DNA synthesis.
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