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Genomically diverse...
Genomically diverse carbapenem resistant Enterobacteriaceae from wild birds provide insight into global patterns of spatiotemporal dissemination
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- Ahlstrom, Christina A. (author)
- US Geol Survey, Alaska Sci Ctr, 4210 Univ Dr, Anchorage, AK 99508 USA.
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- Woksepp, Hanna (author)
- Linnéuniversitetet,Institutionen för medicin och optometri (MEO),Kalmar County Hospital, Sweden,Kalmar Cty Hosp, Dept Dev & Publ Hlth, S-39185 Kalmar, Sweden.;Linnaeus Univ, Dept Med & Optometry, S-39185 Kalmar, Sweden.
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- Sandegren, Linus (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Sweden
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- Mohsin, Mashkoor (author)
- Univ Agr Faisalabad, Inst Microbiol, Faisalabad 38040, Pakistan.,US Geol Survey, Alaska Sci Ctr, 4210 Univ Dr, Anchorage, AK 99508 USA.
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- Hasan, Badrul, 1984- (author)
- Uppsala universitet,Infektionssjukdomar,Institutionen för medicinsk biokemi och mikrobiologi,Anim Bacteriol Sect, Anim Bacteriol Sect Microbial Sci Pests & Dis, Bundoora, Vic, Australia.,Uppsala Univ, Sweden; Anim Bacteriol Sect, Australia
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- Muzyka, Denys (author)
- Inst Expt & Clin Vet Med, Natl Sci Ctr, UA-61023 Kharkiv, Ukraine.
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- Hernandez, Jorge (author)
- Kalmar County Hospital, Sweden,Kalmar Cty Hosp, Dept Clin Microbiol, SE-39185 Kalmar, Sweden.
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- Aguirre, Filip (author)
- Kalmar County Hospital, Sweden,Kalmar Cty Hosp, Dept Clin Microbiol, SE-39185 Kalmar, Sweden.
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- Tok, Atalay (author)
- Uppsala University, Sweden,Uppsala Univ, Dept Med Sci, Zoonosis Sci Ctr, SE-75185 Uppsala, Sweden.
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- Söderman, Jan (author)
- Linköpings universitet,Avdelningen för cellbiologi,Medicinska fakulteten
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- Olsen, Björn (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Ramey, Andrew M. (author)
- US Geol Survey, USA
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- Bonnedahl, Jonas (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Kalmar Cty, Sweden
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US Geol Survey, Alaska Sci Ctr, 4210 Univ Dr, Anchorage, AK 99508 USA Institutionen för medicin och optometri (MEO) (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Science of the Total Environment. - : Elsevier. - 0048-9697 .- 1879-1026. ; 824
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Abstract
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- Carbapenem resistant Enterobacteriaceae (CRE) are a threat to public health globally, yet the role of the environment in the epidemiology of CRE remains elusive. Given that wild birds can acquire CRE, likely from foraging in anthropogenically impacted areas, and may aid in the maintenance and dissemination of CRE in the environment, a spatiotemporal comparison of isolates from different regions and timepoints may be useful for elucidating epidemiological information. Thus, we characterized the genomic diversity of CRE from fecal samples opportunistically collected from gulls (Larus spp.) inhabiting Alaska (USA), Chile, Spain, Turkey, and Ukraine and from black kites (Milvus migrans) sampled in Pakistan and assessed evidence for spatiotemporal patterns of dissemination. Within and among sampling locations, a high diversity of carbapenemases was found, including Klebsiella pneumoniae carbapenemase (KPC), New Delhi metallo-beta-lactamase (NDM), oxacillinase (OXA), and Verona integron Metallo beta-lactamase (VIM). Although the majority of genomic comparisons among samples did not provide evidence for spatial dissemination, we did find strong evidence for dissemination among Alaska, Spain, and Turkey. We also found strong evidence for temporal dissemination among samples collected in Alaska and Pakistan, though the majority of CRE clones were transitory and were not repeatedly detected among locations where samples were collected longitudinally. Carbapenemase-producing hypervirulent K. pneumoniae was isolated from gulls in Spain and Ukraine and some isolates harbored antimicrobial resistance genes conferring resistance to up to 10 different antibiotic classes, including colistin. Our results are consistent with local acquisition of CRE by wild birds with spatial dissemination influenced by intermediary transmission routes, likely involving humans. Furthermore, our results support the premise that anthropogenicallyassociated wild birds may be good sentinels for understanding the burden of clinically-relevant antimicrobial resistance in the local human population.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Zoologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Zoology (hsv//eng)
Keyword
- Carbapenem resistance
- Carbapenemase
- Wildlife
- Zoonotisk ekologi
- Zoonotic Ecology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ahlstrom, Christ ...
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Woksepp, Hanna
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Sandegren, Linus
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Mohsin, Mashkoor
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Hasan, Badrul, 1 ...
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Muzyka, Denys
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show more...
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Hernandez, Jorge
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Aguirre, Filip
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Tok, Atalay
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Söderman, Jan
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Olsen, Björn
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Ramey, Andrew M.
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Bonnedahl, Jonas
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Zoology
- Articles in the publication
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Science of the T ...
- By the university
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Linnaeus University
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Uppsala University
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Linköping University