Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention

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Sex differences in incidence of self-reported adverse drug reactions after percutaneous coronary intervention

Pettersen, T. (författare): Haukeland University Hospital, Norway

Schjott, J. (författare): Haukeland University Hospital, Norway

Allore, H. (författare): Yale School of Medicine, USA

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Bendz, B. (författare): Oslo University Hospital, Norway

Borregaard, B. (författare): Odense University Hospital, Denmark

Fridlund, Bengt (författare): Linnéuniversitetet,Institutionen för hälso- och vårdvetenskap (HV),Centre of Interprofessional Cooperation within Emergency care (CICE)

Hadjistavropoulos, H.D. (författare): University of Regina, Canada

Larsen, A.I. (författare): Stavanger University Hospital, Norway

Nordrehaug, J.E. (författare): University of Bergen, Norway

Rasmussen, T.B. (författare): Herlev-Gentofte University Hospital, Denmark

Rotevatn, S. (författare): Haukeland University Hospital, Norway

Valaker, I. (författare): Western Norway University of Applied Sciences, Norway

Wentzel-Larsen, T. (författare): Haukeland University Hospital, Norway

Norekval, T.M. (författare): Haukeland University Hospital, Norway

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Oxford University Press, 2023
2023
Engelska.
Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 44:Supplement_2

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; visa färre...

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BackgroundDespite experiencing adverse drug reactions (ADRs) more often than men, the proportion of women participating in clinical drug trials is low. Thus, evidence for sex differences in the incidence of ADRs is limited.AimTo determine sex differences in incidence of self-reported ADRs after percutaneous coronary intervention (PCI). Further, to determine whether receiving information about ADRs is associated with sex.MethodsCONCARDPCI is a prospective multicentre cohort study (N=3417) conducted at seven referral PCI centres in two Nordic countries. Clinical data were collected from patients’ medical records. Socio-demographic characteristics were obtained by self-report after PCI. Two questions from the Heart Continuity of Care Questionnaire (HCCQ) were used to determine if information about potential ADRs was received before hospital discharge. De novo created questions were used to determine if patients reported ADRs from prescribed therapy. Questionnaires were distributed two- (T1), six- (T2), and twelve months (T3) after hospital discharge to assess the incidence of self-reported ADRs in a longitudinal perspective. Logistic regression was utilised to scrutinize the aims, reported as odds ratios (ORs) with 95% confidence intervals (CIs).ResultsPatients were predominantly male (78%), with a mean age of 65 years (SD 11). Female patients were older (68, SD 10). Acute coronary syndrome was the most frequent cause of admission for PCI (62%). At T1, 2656 of the included patients responded to the questions from the HCCQ. Of these, 1019 patients (39%) reported being informed of potential ADRs from prescribed therapy, 1075 patients (42%) reported not having been informed, 511 patients (20%) reported ‘Hard to decide’, and 51 (2%) reported ‘Not applicable’. Patients reporting ‘Hard to decide’ or ‘Not applicable’ were excluded from further analysis. Women were less likely to receive information than men (OR 0.58, CI 0.45 – 0.75, p<0.001). For the total study population, 42%, 49% and 40% reported ADRs at T1-T3 respectively. After adjusting for sociodemographic and clinical variables, the incidence of self-reported ADRs were significantly higher in women compared to men at T1 (OR 1.71, CI 1.36 – 2.15, p<0.001), T2 (OR 1.89, CI 1.49 – 2.38, p<0.001), and T3 (OR 1.79, CI 1.40 – 2.28, p<0.001).ConclusionWomen report significantly more ADRs from prescribed therapy than men after PCI. However, they are less likely to receive information about potential ADRs compared to men. Efforts to improve communication on ADRs and gender equity should be a priority.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Omvårdnad (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nursing (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

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Av författaren/redakt...: Pettersen, T.; Schjott, J.; Allore, H.; Bendz, B.; Borregaard, B.; Fridlund, Bengt; visa fler...; Hadjistavropoulo ...; Larsen, A.I.; Nordrehaug, J.E.; Rasmussen, T.B.; Rotevatn, S.; Valaker, I.; Wentzel-Larsen, ...; Norekval, T.M.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Omvårdnad

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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Av lärosätet: Linnéuniversitetet

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