Biological Production of 3-Hydroxypropionic Acid : An Update on the Current Status

• The production of high added-value chemicals from renewable resources is a necessity inour attempts to switch to a more sustainable society. 3-Hydroxypropionic acid (3HP) is a promisingmolecule that can be used for the production of an important array of high added-value chemicals,such as 1,3-propanediol, acrylic acid, acrylamide, and bioplastics. Biological production of 3HP hasbeen studied extensively, mainly from glycerol and glucose, which are both renewable resources.To enable conversion of these carbon sources to 3HP, extensive work has been performed to identifyappropriate biochemical pathways and the enzymes that are involved in them. Novel enzymeshave also been identified and expressed in host microorganisms to improve the production yieldsof 3HP. Various process configurations have also been proposed, resulting in improved conversionyields. The intense research efforts have resulted in the production of as much as 83.8 g/L 3HP fromrenewable carbon resources, and a system whereby 3-hydroxypropionitrile was converted to 3HPthrough whole-cell catalysis which resulted in 184.7 g/L 3HP. Although there are still challengesand difficulties that need to be addressed, the research results from the past four years have been animportant step towards biological production of 3HP at the industrial level.

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Industriell bioteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Industrial Biotechnology (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Industriell bioteknik -- Bioprocessteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Industrial Biotechnology -- Bioprocess Technology (hsv//eng)

Keyword

3-hydroxypropionic acid

metabolic engineering

building-block chemicals

glycerol

platform chemicals

Klebsiella pneumoniae

Escherichia coli

Saccharomyces cerevisiae

Biokemisk processteknik

Biochemical Process Engineering

Publication and Content Type

ref (subject category)

art (subject category)