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Direct regiospecifi...
Direct regiospecific and highly enantioselective intermolecular a-allylic alkylation of aldehydes by combination of transition metal and chiral amine catalysts
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- Afewerki, Samson (author)
- Mittuniversitetet,Institutionen för tillämpad naturvetenskap och design (-2013),Armando Córdova
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(creator_code:org_t)
- 2012
- 2012
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- The direct intermolecular regiospecific and highly enantioselective a-allylic alkylation of linear aldehydes by combination of achiral bench stable Pd(0) complexes and simple chiral amines as co-catalysts is disclosed. The co-catalytic asymmetric chemoselective and regiospecific a-allylic alkylation reaction is linked in tandem with in situ reduction to give the corresponding 2-alkyl alcohols with high enantiomeric ratios (up to 98:2 er). It is also an expeditious entry to valuable 2-alkyl substituted hemiacetals and 2-alkyl-butane-1,4-diols.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- kon (subject category)
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