Emerging manufacturing bioengineering technologies 2: Scaffold designing experiment using titanium scaffolds

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Emerging manufacturing bioengineering technologies 2: Scaffold designing experiment using titanium scaffolds

Bujtar, Peter (author): Southern General Hospital, Glasgow

Simonovics, Janos (author): Southern General Hospital, Glasgow

Koptyug, Andrey, 1956- (author): Mittuniversitetet,Avdelningen för ekoteknik och hållbart byggande,SportsTech

George, Sandor (author): Southern General Hospital, Glasgow

Varadi, Karoly (author): Southern General Hospital, Glasgow

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(creator_code:org_t)

Elsevier BV, 2014
2014
English.
In: British Journal of Oral & Maxillofacial Surgery. - : Elsevier BV. - 0266-4356 .- 1532-1940. ; 52:8, s. e60-e61

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Substantial volume defects of the head and neck oftenrequire customized solutions to improve quality of life likefree flap transfers.Titanium and its alloys are versatile materialsproviding the feature of osteointegration. The conditionswhich facilitate the deposition of lamellar bone are underextensive research. Our project aimed to determine whethertitanium can function as a scaffold - unlike simple plates - toenhance bone regeneration for load bearing structures. Thereaction of stem cells to scaffolds with varying stiffness willbe presented.Additive manufacturing were used to produce a variety ofscaffolds to optimize titanium structures. Electric beam melting(EBM) manufacturing allowed us to optimize the elasticmodulus (Young) of the titanium to match with cadaveric bone from a previous project. Multidirectional mechanicaltests were performed on the various designs of titanium cellstructures (n=80). The predictability and quality of manufacturingwas assessed statistically and also with scanningelectron microscope (SEM).The results demonstrated structures matching the mechanicalproperties of bone and even anisotropy as our resultssuggest 3GPa elasticity. This allows the possibility to buildregenerating bone with predictable properties. In addition,predictable patterning - unlike etching and sandblasting - ofmicroscopic (nano) features found to be significant and nonhomogenous simple repetitive patterns provide better cellularresponse.The benefit that tissue engineering techniques offer isdecreased morbidity, relative independence from donor site,with a highly specific and customized shape. Titanium basedreconstruction constructs seems to offer an alternative futurefor bony reconstruction.

Subject headings

TEKNIK OCH TEKNOLOGIER -- Materialteknik -- Metallurgi och metalliska material (hsv//swe)
ENGINEERING AND TECHNOLOGY -- Materials Engineering -- Metallurgy and Metallic Materials (hsv//eng)
TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Annan medicinteknik (hsv//swe)
ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Other Medical Engineering (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)

Keyword

Additive manufacturing
implants
scaffolds
Ti64

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ref (subject category)
art (subject category)

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By the author/editor: Bujtar, Peter; Simonovics, Jano ...; Koptyug, Andrey, ...; George, Sandor; Varadi, Karoly

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ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Materials Engine ...; and Metallurgy and M ...

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Other Medical En ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dentistry

Articles in the publication: British Journal ...

By the university: Mid Sweden University

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