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Association of infl...
Association of inflammatory bowel disease in first-degree relatives with risk of colorectal cancer : A nationwide case-control study in Sweden
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- Wang, Kai (author)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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- Olén, Ola (author)
- Karolinska Institutet
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- Emilsson, Louise (author)
- Karolinska Institutet
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- Khalili, Hamed (author)
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Institute of Environmental Medicine, Nutrition Epidemiology, Karolinska Institutet, Solna, Sweden
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- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Song, Mingyang (author)
- Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, MA, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
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- Ludvigsson, Jonas F., 1969- (author)
- Karolinska Institutet
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Karolinska Institutet Department of Epidemiology, Harvard TH. Chan School of Public Health, Boston, MA, USA (creator_code:org_t)
- 2023-02-20
- 2023
- English.
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In: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 152:11, s. 2303-2313
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This study aims to assess the association between inflammatory bowel disease (IBD) history in first-degree relatives (FDRs) and colorectal cancer (CRC) risk. We conducted a nationwide case-control study in Sweden among 69,659 CRC cases and 343,032 non-CRC controls matched on age, sex, birth year, and residence county. Through linkage of multi-generation register and the nationwide ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) cohort, we ascertained IBD diagnoses among parents, full siblings, and offspring of the index individuals. Odds ratios (ORs) of CRC associated with IBD family history were calculated using conditional logistic regression. 2.2% of both CRC cases (1,566/69,659) and controls (7,676/343,027) had ≥1 FDR with IBD history. After adjusting for family history of CRC, we observed no increased risk of CRC in FDRs of IBD patients (OR, 0.96; 95%CI, 0.91-1.02). The null association was consistent according to IBD subtype (Crohn's disease or ulcerative colitis), number of FDRs with IBD (1 or ≥2), age at first IBD diagnosis in FDRs (<18, 18-39, 40-59, or ≥60 years), maximum location/extent of IBD, or FDR relation (parent, sibling, or offspring). The null association remained for early-onset CRC (diagnosed at age <50 years). In conclusion, IBD history in FDRs was not associated with an increased risk of CRC. Our findings suggest that extra screening for CRC may not be needed in the offspring, siblings, or parents of IBD patients, and strengthen the theory that it is the actual inflammation or atypia of the colon in IBD patients that confers the increased CRC risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Colorectal cancer
- family history
- first-degree relatives
- inflammatory bowel disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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