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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05863naa a2200505 4500 | |
| 001 | oai:DiVA.org:oru-105541 | |
| 003 | SwePub | |
| 008 | 230417s2023 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:liu-196881 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1055412 URI |
| 024 | 7 | a https://doi.org/10.1053/j.jvca.2023.03.0132 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1968812 URI |
| 040 | a (SwePub)orud (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Tornudd, Mattiasu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)n/a |
| 245 | 1 0 | a Platelet Function is Preserved After Moderate Cardiopulmonary Bypass Times But Transiently Impaired After Protamine |
| 264 | 1 | b Elsevier,c 2023 |
| 338 | a print2 rdacarrier | |
| 520 | a OBJECTIVES: Previous studies have described impaired platelet function after cardiopulmonary bypass (CPB). Whether this is still valid in contemporary cardiac surgery is unclear. This study aimed to quantify changes in function and number of platelets during CPB in a present-day cardiac surgery cohort.DESIGN: Prospective, controlled clinical study.SETTING: A single-center university hospital.PARTICIPANTS: Thirty-nine patients scheduled for coronary artery bypass graft surgery with CPB.INTERVENTIONS: Platelet function and numbers were measured at 6 timepoints in 39 patients during and after coronary artery bypass graft surgery; at baseline before anesthesia, at the end of CPB, after protamine administration, at intensive care unit (ICU) arrival, 3 hours after ICU arrival, and on the morning after surgery. MEASUREMENTS ANDMAIN RESULTS: Platelet function was assessed with impedance aggregometry and flow cytometry. Platelet numbers are expressed as actual concentration and as numbers corrected for dilution using hemoglobin as a reference marker. There was no consistent impairment of platelet function during CPB with either impedance aggregometry or flow cytometry. After protamine administration, a decrease in platelet function was seen with impedance aggregometry and for some markers of activation with flow cytometry. Platelet function was restored 3 hours after arrival in the ICU. During CPB (85.0 ± 21 min), the number of circulating platelets corrected for dilution increased from 1.73 ± 0.42 × 109/g to 1.91 ± 0.51 × 109/g (p < 0.001).CONCLUSIONS: During cardiac surgery with moderate CPB times, platelet function was not impaired, and no consumption of circulating platelets could be detected. Administration of protamine transiently affected platelet function. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Anestesi och intensivvård0 (SwePub)302012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Anesthesiology and Intensive Care0 (SwePub)302012 hsv//eng |
| 653 | a Cardiac surgery | |
| 653 | a cardiopulmonary bypass | |
| 653 | a flow cytometry | |
| 653 | a impedance aggegometry | |
| 653 | a platelet function | |
| 653 | a protamine | |
| 700 | 1 | a Ramström, Sofia,d 1973-u Linköpings universitet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Chemistry and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden; Cardiovascular Research Centre, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Klinisk kemi,Orebro Univ, Sweden4 aut0 (Swepub:liu)sofra86 |
| 700 | 1 | a Kvitting, John-Peder Escobaru Department of Cardiothoracic Surgery, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Norway; Univ Oslo, Norway4 aut |
| 700 | 1 | a Alfredsson, Joakimu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US4 aut0 (Swepub:liu)joaal38 |
| 700 | 1 | a Nyberg, Linneau Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland,Region Östergötland, Klinisk kemi4 aut0 (Swepub:liu)n/a |
| 700 | 1 | a Bjorkman, Eriku Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland,Region Östergötland, Klinisk kemi4 aut0 (Swepub:liu)n/a |
| 700 | 1 | a Berg, Sörenu Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Thorax-kärlkliniken i Östergötland4 aut0 (Swepub:liu)sorbe67 |
| 710 | 2 | a Linköpings universitetb Avdelningen för diagnostik och specialistmedicin4 org |
| 773 | 0 | t Journal of Cardiothoracic and Vascular Anesthesiad : Elsevierg 37:7, s. 1110-1120q 37:7<1110-1120x 1053-0770x 1532-8422 |
| 856 | 4 | u https://doi.org/10.1053/j.jvca.2023.03.013y Fulltext |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1791495/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-105541 |
| 856 | 4 8 | u https://doi.org/10.1053/j.jvca.2023.03.013 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-196881 |
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