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Multidrug-resistant Neisseria gonorrhoeae isolate SE690 : mosaic penA-60.001 gene causing ceftriaxone resistance internationally has spread to the more antimicrobial- susceptible genomic lineage, Sweden, September 2022

Golparian, Daniel, 1984- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine
Vestberg, Nora (author)
Department of Clinical Microbiology, Karolinska University Hospital, Huddinge, Sweden
Södersten, Wiktor (author)
Department of Venerology at Karolinska University Hospital, Stockholm, Sweden
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Jacobsson, Susanne, 1974- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine
Ohnishik, Makoto (author)
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan
Fang, Hong (author)
Karolinska Institutet
Bhattarai, Karin Haij (author)
Department of Clinical Microbiology, Karolinska University Hospital, Huddinge, Sweden
Unemo, Magnus, 1970- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Ӧrebro University, Ӧrebro, Sweden; Institute for Global Health, University College London (UCL), London, United Kingdom
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 (creator_code:org_t)
European Centre for Disease Prevention and Control, 2023
2023
English.
In: Eurosurveillance. - : European Centre for Disease Prevention and Control. - 1025-496X .- 1560-7917. ; 28:10
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We report a ceftriaxone-resistant, multidrug-resist-ant urogenital Neisseria gonorrhoeae in a female sex worker in Sweden, September 2022, who was treated with ceftriaxone i g, but did not return for test-of-cure. Whole genome sequencing of isolate SE690 identified MLST ST8i30, NG-STAR CCi885 (new NG-STAR ST4859) and mosaic penA-6o.oo1. The latter, causing ceftriax-one resistance in the internationally spreading FC428 clone, has now also spread to the more antimicrobial -susceptible genomic lineage B, showing that strains across the gonococcal phylogeny can develop ceftri-axone resistance.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

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