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A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58

Reid, Cameron J (author)
iThree Institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia
Cummins, Max L (author)
iThree Institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia
Börjesson, Stefan, 1979- (author)
Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), Uppsala, Sweden; Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden
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Brouwer, Michael S M (author)
Wageningen Bioveterinary Research, Lelystad, Netherlands
Hasman, Henrik (author)
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen S, Denmark
Hammerum, Anette M (author)
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen S, Denmark
Roer, Louise (author)
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen S, Denmark
Hess, Stefanie (author)
Institute of Microbiology, Technische Universität Dresden, Dresden, Germany
Berendonk, Thomas (author)
Institute of Hydrobiology, Technische Universität Dresden, Dresden, Germany
Nešporová, Kristina (author)
CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czech Republic; Department of Biology and Wildlife Disease, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic
Haenni, Marisa (author)
Université de Lyon-ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France
Madec, Jean-Yves (author)
Université de Lyon-ANSES, Unité Antibiorésistance et Virulence Bactériennes, Lyon, France
Bethe, Astrid (author)
Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
Michael, Geovana B (author)
Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
Schink, Anne-Kathrin (author)
Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
Schwarz, Stefan (author)
Institute of Microbiology and Epizootics, Centre for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Veterinary Centre for Resistance Research (TZR), Freie Universität Berlin, 14163, Berlin, Germany
Dolejska, Monika (author)
CEITEC VETUNI, University of Veterinary Sciences Brno, Brno, Czech Republic; Department of Biology and Wildlife Disease, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences Brno, Brno, Czech Republic; Biomedical Center, Charles University, Charles, Czech Republic
Djordjevic, Steven P (author)
iThree Institute, University of Technology Sydney, Ultimo, NSW, 2007, Australia
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 (creator_code:org_t)
2022-02-03
2022
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
Related links:
https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Escherichia coli ST58 has recently emerged as a globally disseminated uropathogen that often progresses to sepsis. Unlike most pandemic extra-intestinal pathogenic E. coli (ExPEC), which belong to pathogenic phylogroup B2, ST58 belongs to the environmental/commensal phylogroup B1. Here, we present a pan-genomic analysis of a global collection of 752 ST58 isolates from diverse sources. We identify a large ST58 sub-lineage characterized by near ubiquitous carriage of ColV plasmids, which carry genes encoding virulence factors, and by a distinct accessory genome including genes typical of the Yersiniabactin High Pathogenicity Island. This sub-lineage includes three-quarters of all ExPEC sequences in our study and has a broad host range, although poultry and porcine sources predominate. By contrast, strains isolated from cattle often lack ColV plasmids. Our data indicate that ColV plasmid acquisition contributed to the divergence of the major ST58 sub-lineage, and different sub-lineages inhabit poultry, swine and cattle.

Subject headings

NATURVETENSKAP  -- Biologi -- Mikrobiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Microbiology (hsv//eng)

Keyword

extended-spectrum
multidrug-resistant
antimicrobial resistance
p-fimbriae
enterobacteria
ceaevirulence
sequence
strains
clones
surveillance

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ref (subject category)
art (subject category)

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