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Ripe papaya pectins...
Ripe papaya pectins inhibit the proliferation of colon cancer spheroids and the formation of chemically induced aberrant crypts in rats colons
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- Donadio, Janaina L. S. (author)
- University of São Paulo, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, São Paulo SP, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers, São Paulo Research Foundation, São Paulo SP, Brazil
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- Ramos do Prado, Samira Bernardino, 1990- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Center
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- Soares, Caroline Giacomelli (author)
- University of São Paulo, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, São Paulo SP, Brazil
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- Tamarossi, Rodrigo Invernort (author)
- University of São Paulo, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, São Paulo SP, Brazil
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- Heidor, Renato (author)
- University of São Paulo, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, São Paulo SP, Brazil
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- Moreno, Fernando Salvador (author)
- University of São Paulo, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, São Paulo SP, Brazil
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- Fabi, Joao Paulo (author)
- University of São Paulo, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, São Paulo SP, Brazil; Food Research Center (FoRC), CEPID-FAPESP, Research Innovation and Dissemination Centers, São Paulo Research Foundation, São Paulo SP, Brazil; Food and Nutrition Research Center (NAPAN), University of São Paulo, São Paulo SP, Brazil
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Carbohydrate Polymers. - : Elsevier. - 0144-8617 .- 1879-1344. ; 331
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Pectins are a class of soluble polysaccharides that can have anticancer properties through several mechanisms. This study aimed to characterize the molecular structure of water-soluble fractions (WSF) derived from ripe and unripe papayas and assess their biological effects in two models: the 3D colon cancer spheroids to measure cell viability and cytotoxicity, and the in vivo model to investigate the inhibition of preneoplastic lesions in rats. WSF yield was slightly higher in ripe papaya, and both samples mainly consisted of pectin. Both pectins inhibited the growth of colon cancer HT29 and HCT116 spheroids. Unripe pectin disturbed HT29/NIH3T3 spheroid formation, decreased HCT116 spheroid viability, and increased spheroid cytotoxicity. Ripe pectin had a more substantial effect on the reduction of spheroid viability for HT29 spheroids. Furthermore, in vivo experiments on a rat model revealed a decrease in aberrant crypt foci (ACF) formation for both pectins and increased apoptosis in colonocytes for ripe papaya pectins. The results suggest potential anticancer properties of papaya pectin, with ripe pectin showing a higher potency.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Pectin
- Anticancer
- Spheroids
- Wistar rat
- Aberrant crypt foci
- Papaya
Publication and Content Type
- ref (subject category)
- art (subject category)
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