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HbA1c and the risk ...
HbA1c and the risk of developing peripheral neuropathy in childhood-onset type 1 diabetes : A follow-up study over 3 decades
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- Baldimtsi, Evangelia (author)
- Department of Acute Internal Medicine and Geriatrics in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- Amezcua, Salvador (author)
- Department of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden
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- Ulander, Martin (author)
- Department of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden
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- Hyllienmark, Lars (author)
- Clinical Neurophysiology, Karolinska University Hospital, and Karolinska Institute, Stockholm, Sweden
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- Olausson, Håkan (author)
- Department of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden
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- Ludvigsson, Johnny (author)
- Department of Biomedical and Clinical Sciences, Crown Princess Victoria's Children Hospital and Division of Pediatrics, Linköping University, Linköping, Sweden
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- Wahlberg, Jeanette, 1969- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Acute Internal Medicine and Geriatrics in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
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- John Wiley & Sons, 2024
- 2024
- English.
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In: Diabetes/Metabolism Research Reviews. - : John Wiley & Sons. - 1520-7552 .- 1520-7560. ; 40:5
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- AIMS: We have evaluated long-term weighted mean HbA1c (wHbA1c), HbA1c variability, diabetes duration, and lipid profiles in relation to the development of diabetic peripheral neuropathy (DPN), nephropathy, and retinopathy in childhood-onset type 1 diabetes.MATERIALS AND METHODS: In a longitudinal cohort study, 49 patients (21 women) with childhood-onset type 1 diabetes were investigated with neurophysiological measurements, blood tests, and clinical examinations after a diabetes duration of 7.7 (±3.3) years (baseline) and followed with repeated examinations for 30.6 (±5.2) years. We calculated wHbA1c by integrating the area under all HbA1c values since the diabetes diagnosis. Lipid profiles were analysed in relation to the presence of DPN. Long-term fluctuations of HbA1c variability were computed as the standard deviation of all HbA1c measurements. Data regarding the presence of other diabetes complications were retrieved from medical records.RESULTS: In this follow-up study, 51% (25/49) of the patients fulfilled electrophysiological criteria for DPN. In nerve conduction studies, there was a deterioration in the amplitudes and conduction velocities for the median, peroneal, and sural nerves over time. Patients with DPN had a longer duration of diabetes, higher wHbA1c, and increased HbA1c variability. The lowest wHbA1c value associated with the development of DPN was 62 mmol/mol (7.8%). The presence of albuminuria and retinopathy was positively correlated with the presence of neuropathy.CONCLUSIONS: More than half of the patients had developed DPN after 30 years. None of the patients who developed DPN had a wHbA1c of less than 62 mmol/mol (7.8%).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- HbA1c target
- cohort study
- longitudinal study
- peripheral neuropathy
- type 1 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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