id:"swepub:oai:DiVA.org:oru-12137"
Search: id:"swepub:oai:DiVA.org:oru-12137" > Butyrate-induced tr...
- 1 of 1
- Previous record
- Next record
- To hitlist
Butyrate-induced transcriptional changes in human colonic mucosa
- Vanhoutvin, Steven A. L. W. (author)
- Troost, Freddy J. (author)
- Hamer, Henrike M. (author)
- show more...
- Lindsey, Patrick J. (author)
- Koek, Ger H. (author)
- Jonkers, Daisy M. A. E. (author)
- Kodde, Andrea (author)
- Venema, Koen (author)
- show less...
- (creator_code:org_t)
- 2009-08-25
- 2009
- English.
- In: PLoS one. - : Public Library of Science (PLoS). - 1932-6203. ; 4:8, s. e6759-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- BACKGROUND: Fermentation of dietary fiber in the colon results in the production of short chain fatty acids (mainly propionate, butyrate and acetate). Butyrate modulates a wide range of processes, but its mechanism of action is mostly unknown. This study aimed to determine the effects of butyrate on the transcriptional regulation of human colonic mucosa in vivo. METHODOLOGY/PRINCIPAL FINDINGS: Five hundred genes were found to be differentially expressed after a two week daily butyrate administration with enemas. Pathway analysis showed that the butyrate intervention mainly resulted in an increased transcriptional regulation of the pathways representing fatty acid oxidation, electron transport chain and oxidative stress. In addition, several genes associated with epithelial integrity and apoptosis, were found to be differentially expressed after the butyrate intervention. CONCLUSIONS/SIGNIFICANCE: Colonic administration of butyrate in concentrations that can be achieved by consumption of a high-fiber diet enhances the maintenance of colonic homeostasis in healthy subjects, by regulating fatty acid metabolism, electron transport and oxidative stress pathways on the transcriptional level and provide for the first time, detailed molecular insight in the transcriptional response of gut mucosa to butyrate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Gastroenterology
- Gastroenterologi
- Medicine
- Medicin
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Vanhoutvin, Stev ...
- Troost, Freddy J ...
- Hamer, Henrike M ...
- Lindsey, Patrick ...
- Koek, Ger H.
- Jonkers, Daisy M ...
- show more...
- Kodde, Andrea
- Venema, Koen
- Brummer, Robert
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Gastroenterology ...
- Articles in the publication
- PLoS one
- By the university
- Örebro University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
