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Elution of antitransglutaminase antibodies from duodenal biopsies : a novel approach in the diagnosis of celiac disease
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- Rathsman, Sandra (author)
- Department of Laboratory Medicine/Microbiology, Örebro University Hospital, Örebro, Sweden
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- Tysk, Curt, 1949- (author)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Division of Gastroenterology, Department of Medicine, Örebro University Hospital, Örebro, Sweden
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- Eriksson, Sune (author)
- Department of Laboratory Medicine/Pathology, Örebro University Hospital, Örebro, Sweden
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- (creator_code:org_t)
- 2012-03-24
- 2012
- English.
- In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - Hoboken, USA : Wiley-Blackwell. - 0903-4641 .- 1600-0463. ; 120:8, s. 666-674
- Journal article (peer-reviewed)
Abstract
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- Celiac disease (CeD) is a disease more prevalent and multisymptomatic than was earlier recognized. Whereas prompt initiation of gluten-free diet (GFD) is beneficial in relieving the symptoms, an accurate CeD diagnosis is necessary also to avoid years of restricted diet on uncertain grounds. We propose a new diagnostic method, based on elution of deposited antibodies against transglutaminase (anti-tTG) from duodenal biopsies in patients with symptoms and screening serology analyses suggestive of CeD. The eluates were analyzed in a Phadia 250 fluoroimmunoassay, demonstrating elevated concentrations of anti-tTG in CeD patients, corresponding to serology and histopathology findings. In one case histology was inconclusive, displaying only unspecific inflammation, but eluted anti-tTG was positive. This patient has clinically improved following GFD. We conclude that our novel method represents a new tool in the diagnostic work up in CeD. The detection of deposited anti-tTG at the site of inflammation appears to provide a high sensitivity and specificity using a technique that is quick, simple and reliable. Further studies are needed for optimization and elucidation of suitable applications for this elution method.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Celiac disease
- antitransglutaminase antibodies
- elution
- borderline cases
- Medicin
- Medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
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