Sökning: id:"swepub:oai:DiVA.org:oru-36153" >
Are increased level...
Are increased levels of systemic oxidative stress and inflammation associated with age-related cataract?
-
- Selin, Jinjin Zheng (författare)
- Karolinska Institutet
-
- Lindblad, Birgitta Ejdervik, 1955- (författare)
- Örebro universitet,Institutionen för hälsovetenskap och medicin,Region Örebro län,Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Ophthalmology, Örebro University Hospital, Örebro, Sweden
-
- Rautiainen, Susanne (författare)
- Karolinska Institutet
-
visa fler...
-
- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Ortopedi
-
- Morgenstern, Ralf (författare)
- Karolinska Institutet
-
- Bottai, Matteo (författare)
- Karolinska Institutet
-
- Basu, Samar (författare)
- Uppsala universitet,Oxidativ stress och inflammation
-
- Wolk, Alicja (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- Mary Ann Liebert, 2014
- 2014
- Engelska.
-
Ingår i: Antioxidants and Redox Signaling. - : Mary Ann Liebert. - 1523-0864 .- 1557-7716. ; 21:5, s. 700-704
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F-2 alpha (PGF(2 alpha); as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-PGF(2 alpha) (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study, including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection that, women with higher levels of urinary 8-iso-PGF(2 alpha) as compared with lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF(2 alpha) levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Molecular Biology
- Molekylärbiologi
- Biokemi
- Biochemistry
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas