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Protection against clinical pertussis induced by whole-cell pertussis vaccination is related to primo-immunisation intervals
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- Silfverdal, Sven Arne (author)
- Department of Paediatrics, Örebro University Hospital, Örebro, Sweden
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- Ehlin, A. (author)
- Clinical Epidemiology Unit, Department of Medicine, Karolinska Hospital, Karolinska Institutet, Sweden
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- Montgomery, Scott M. (author)
- Karolinska Institutet,Örebro universitet,Hälsoakademin,Clinical Research Centre, Örebro University Hospital, Örebro, Sweden
- (creator_code:org_t)
- Guildford : Butterworths, 2007
- 2007
- English.
- In: Vaccine. - Guildford : Butterworths. - 0264-410X .- 1873-2518. ; 25:43, s. 7510-7515
- Journal article (peer-reviewed)
Abstract
Subject headings
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- AIMS: Information on subjects who had at least three immunisations against pertussis was provided by longitudinal data from the 1970 British Cohort Study (BCS70) and used to assess whether three whole-cell pertussis (wP) immunisations given within less than 5 months confer less effective protection in childhood compared with a schedule with a longer interval.METHODS: Age at pertussis infection was the dependent variable in a Cox regression analysis, to investigate associations with duration between first and third pertussis immunisation; with third immunisation modelled as a time-dependent covariate. Adjustment was for number of pertussis immunisations (three or four), sex, social class and other potential confounding factors.RESULTS: A total of 8545 children were included in the analysis and 556 had a history of whooping cough. A duration of over 4 months between first and third pertussis immunisations is statistically significantly associated with a reduced risk of pertussis infection by age 10 years, compared with three immunisations given over a shorter period, producing a statistically significant adjusted hazard ratio of 0.74 (0.62-0.92). A fourth immunisation against pertussis further enhanced the protective effect with a hazard ratio of 0.59 (0.44-0.82).CONCLUSION: These results were based on a historical UK cohort using wP vaccine, and indicate that a vaccination schedule with an interval between the immunisations greater than 4 months, and also including a fourth immunisation, would be more effective in this population than a three dose schedule within a shorter interval without booster.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Adult
- Child
- Child; Preschool
- Cohort Studies
- Female
- Great Britain
- Humans
- Immunization Schedule
- Infant
- Infant; Newborn
- Male
- Pertussis Vaccine/administration & dosage/*immunology
- Proportional Hazards Models
- Time Factors
- Vaccination/*methods/statistics & numerical data
- Whooping Cough/*immunology/prevention & control
- MEDICINE
- MEDICIN
- Immunology
- Immunologi
- Immunologi
- Immunology
- medicin
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- art (subject category)
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- Örebro University
- Umeå University
- Karolinska Institutet
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