Decreased binding capacity (Bmax) of muscarinic acetylcholine receptors in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD)

Johansson, Jessica, 1977- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Experimentell neuropsykiatri

Landgren, Magnus, 1955 (author): Unit of Neurodevelopmental Disorders, Department of Paediatrics, Skaraborg Hospital, Mariestad, Sweden

Fernell, Elisabeth, 1948 (author): Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre

Lewander, Tommy (author): Department of Neuroscience, Psychiatry, Uppsala University Hospital, Uppsala, Sweden

Venizelos, Nikolaos, 1946- (author): Örebro universitet,Institutionen för hälsovetenskap och medicin,Experimentell neuropsykiatri

(creator_code:org_t)

2013-02-07
2013
English.
In: ADHD Attention Deficit and Hyperactivity Disorders. - Berlin, Germany : Springer Berlin/Heidelberg. - 1866-6116 .- 1866-6647. ; 5:3, s. 267-271

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Abstract Subject headings

Monoaminergic dysregulation is implicated in attention-deficit/hyperactivity disorder (ADHD), and methylphenidate and amphetamines are the most frequently prescribed pharmacological agents for treating ADHD. However, it has recently been proposed that the core symptoms of the disorder might be due to an imbalance between monoaminergic and cholinergic systems. In this study, we used fibroblast cell homogenates from boys with and without ADHD as an extraneural cell model to examine the cholinergic receptor density, that is, muscarinic acetylcholine receptors (mAChRs). We found that the binding capacity (Bmax) of [³H] Quinuclidinyl benzilate (³H-QNB) to mAChRs was decreased by almost 50 % in the children with ADHD (mean = 30.6 fmol/mg protein, SD = 25.6) in comparison with controls [mean = 63.1 fmol/mg protein, SD = 20.5, p ≤ 0.01 (Student's unpaired t test)]. The decreased Bmax indicates a reduced cholinergic receptor density, which might constitute a biomarker for ADHD. However, these preliminary findings need to be replicated in larger ADHD and comparison cohorts

By the author/editor: Johansson, Jessi ...; Landgren, Magnus ...; Fernell, Elisabe ...; Lewander, Tommy; Venizelos, Nikol ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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