id:"swepub:oai:DiVA.org:oru-45755"
Sökning: id:"swepub:oai:DiVA.org:oru-45755" > DNA methylation and...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04008naa a2200493 4500 | |
| 001 | oai:DiVA.org:oru-45755 | |
| 003 | SwePub | |
| 008 | 150909s2015 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-108160 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-457552 URI |
| 024 | 7 | a https://doi.org/10.1007/s13277-015-3228-22 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1081602 URI |
| 040 | a (SwePub)orud (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Farkas, Sanja A.,d 1983-u Örebro universitet,Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)sfs |
| 245 | 1 0 | a DNA methylation and expression of the folate transporter genes in colorectal cancer |
| 264 | c 2015-02-21 | |
| 264 | 1 | b S. Karger,c 2015 |
| 338 | a print2 rdacarrier | |
| 500 | a Funding Agencies:Lions Cancer Foundation, NyckelfondenResearch committee of Örebro county council | |
| 520 | a Folate has a central role in the cell metabolism. This study aims to explore the DNA methylation pattern of the folate transporter genes FOLR1, PCFT, and RFC1 as well as the corresponding protein expressions in colorectal cancer (CRC) tissue and adjacent non-cancerous mucosa (ANCM). Our results showed statistically significant differences in the DNA-methylated fraction of all three genes at several gene regions; we identified three differentially methylated CpG sites in the FOLR1 gene, five CpG sites in the PCFT gene, and six CpG sites in the RFC1 gene. There was a pronounced expression of the FR alpha and RFC proteins in both the CRC and ANCM tissues, though the expression was attenuated in cancer compared to the paired ANCM tissues. The PCFT protein was undetectable or expressed at a very low level in both tissue types. Higher methylated fractions of the CpG sites 3-5 in the RFC1 gene were associated with a lower protein expression, suggestive of epigenetic regulation by DNA methylation of the RFC1 gene in the colorectal cancer. Our results did not show any association between the RFC and FR alpha protein expression and tumor stage, TNM classification, or tumor location. In conclusion, this is the first study to simultaneously evaluate both DNA methylation and protein expression of all three folate transporter genes, FOLR1, PCFT, and RFC1, in colorectal cancer. The results encourage further investigation into the possible prognostic implications of folate transporter expression and DNA methylation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
| 653 | a CpG | |
| 653 | a T-DMR | |
| 653 | a Reduced folate carrier | |
| 653 | a CRC | |
| 653 | a Immunohistochemistry | |
| 653 | a Onkologi | |
| 653 | a Oncology | |
| 700 | 1 | a Befekadu, Rahel,d 1968-u Örebro universitet,Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)rlbu |
| 700 | 1 | a Hahn-Strömberg, Victoria,d 1971-u Örebro universitet,Institutionen för hälsovetenskap och medicin4 aut0 (Swepub:oru)vhg |
| 700 | 1 | a Nilsson, Torbjörn K.u Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)toni0049 |
| 710 | 2 | a Örebro universitetb Institutionen för hälsovetenskap och medicin4 org |
| 773 | 0 | t Tumor Biologyd : S. Kargerg 36:7, s. 5581-5590q 36:7<5581-5590x 1010-4283x 1423-0380 |
| 856 | 4 | u https://doi.org/10.1007/s13277-015-3228-2y Fulltext |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-45755 |
| 856 | 4 8 | u https://doi.org/10.1007/s13277-015-3228-2 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-108160 |
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