Sökning: onr:"swepub:oai:DiVA.org:oru-46356" >
Dietary trans-10, c...
Dietary trans-10, cis-12-conjugated linoleic acid alters fatty acid metabolism and microbiota composition in mice
-
- Marques, Tatiana M. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
-
- Wall, Rebecca, 1979- (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Ireland,Nutrition-Gut-Brain Interactions Research Centre
-
- O'Sullivan, Orla (författare)
- Teagasc Food Research Centre, Moorepark, Fermoy, Ireland
-
visa fler...
-
- Fitzgerald, Gerald F. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Department of Microbiology, University College Cork, Cork, Ireland
-
- Shanahan, Fergus (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
-
- Quigley, Eamonn M. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland
-
- Cotter, Paul D. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Ireland
-
- Cryan, John F. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland
-
- Dinan, Timothy G. (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Department of Psychiatry, University College Cork, Cork, Ireland
-
- Ross, R. Paul (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Ireland
-
- Stanton, Catherine (författare)
- Alimentary Pharmabiotic Centre, Biosciences Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Ireland
-
visa färre...
-
(creator_code:org_t)
- Cambridge, United Kingdom : Cambridge University Press, 2015
- 2015
- Engelska.
-
Ingår i: British Journal of Nutrition. - Cambridge, United Kingdom : Cambridge University Press. - 0007-1145 .- 1475-2662. ; 113:5, s. 728-738
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The main aim of the present study was to investigate the effects of dietary trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) on intestinal microbiota composition and SCFA production. C57BL/6 mice (n 8 per group) were fed a standard diet either supplemented with t10c12-CLA (0·5 %, w/w) (intervention) or with no supplementation (control), daily for 8 weeks. Metabolic markers (serum glucose, leptin, insulin and TAG, and liver TAG) were assessed by ELISA commercial kits, tissue long-chain fatty acids and caecal SCFA by GC, and microbial composition by 16S rRNA pyrosequencing. Dietary t10c12-CLA significantly decreased visceral fat mass (P< 0·001), but did not affect body weight (intervention), when compared with no supplementation (control). Additionally, lipid mass and composition were affected by t10c12-CLA intake. Caecal acetate, propionate and isobutyrate concentrations were higher (P< 0·05) in the t10c12-CLA-supplemented group than in the control group. The analysis of the microbiota composition following 8 weeks of t10c12-CLA supplementation revealed lower proportions of Firmicutes (P= 0·003) and higher proportions of Bacteroidetes (P= 0·027) compared with no supplementation. Furthermore, t10c12-CLA supplementation for 8 weeks significantly altered the gut microbiota composition, harbouring higher proportions of Bacteroidetes, including Porphyromonadaceae bacteria previously linked with negative effects on lipid metabolism and induction of hepatic steatosis. These results indicate that the mechanism of dietary t10c12-CLA on lipid metabolism in mice may be, at least, partially mediated by alterations in gut microbiota composition and functionality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Trans-10
- cis-12-Conjugated linoleic acid
- Intestinal microbiota
- Lipid metabolism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Marques, Tatiana ...
-
Wall, Rebecca, 1 ...
-
O'Sullivan, Orla
-
Fitzgerald, Gera ...
-
Shanahan, Fergus
-
Quigley, Eamonn ...
-
visa fler...
-
Cotter, Paul D.
-
Cryan, John F.
-
Dinan, Timothy G ...
-
Ross, R. Paul
-
Stanton, Catheri ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Näringslära
- Artiklar i publikationen
-
British Journal ...
- Av lärosätet
-
Örebro universitet