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Sökning: id:"swepub:oai:DiVA.org:oru-49021" > Defunctioning stoma...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003934nam a2200469 4500
001oai:DiVA.org:oru-49021
003SwePub
008160308s2016 | |||||||||||000 ||eng|
020 a 9789175291390q print
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-490212 URI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a vet2 swepub-contenttype
072 7a dok2 swepub-publicationtype
100a Floodeen, Hannah,d 1981-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)hfn
2451 0a Defunctioning stoma in low anterior resection of the rectum for cancer :b Aspects of stoma reversal, anastomotic leakage, anorectal function, and cost-effectiveness
264 1a Örebro :b Örebro university,c 2016
300 a 56 s.
338 a electronic2 rdacarrier
490a Örebro Studies in Medicine,x 1652-4063 ;v 143
520 a Rectal cancer is a common malignancy treated with surgical resection and curative intent in the majority of cases. One treatment option is low anterior resection (LAR) with preserved bowel continuity, often involving the formation of a temporary defunctioning stoma (DS).The general aim of this thesis was to improve understanding of the role of DS in rectal cancer surgery with regard to timing of stoma reversal and development of anastomotic leakage (AL), impact on long-term anorectal function (AF), as well as aspects of cost-effectiveness.Study I addressed the timing of stoma reversal following LAR. We found that 19% of reversed patients were reversed within 4 months of LAR, while 81% of reversals were delayed. In 58% of delayed reversals the delay was due to low priority on surgical waiting lists.Studies II-IV were based on 234 patients randomized to receive a DS or no DS following LAR. Study II compared patients with AL following LAR diagnosed during the initial hospital stay (early leakage, EL) with patients diagnosed after hospital discharge (late leakage, LL). LL was more common in females, and originated more frequently from the transverse stapler line. EL was more common in males, and originated more frequently from the circular stapler line. Study III assessed AF 5 years after LAR with regard to whether patients initially had a DS or no DS. We found no difference in AF between the two randomized groups. When comparing with a 1-year follow-up in the same patient cohort, there were no further changes in AF over time. Study III assessed necessary healthcare resources and cost within 5 years of LAR, depending on whether patients initially had a DS or no DS. The overall cost analysis revealed a higher cost for patients randomized to DS, regardless of the cost-savings associated with a reduced frequency of anastomotic leakage.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a rectal cancer
653 a low anterior resection
653 a defunctioning stoma
653 a stoma reversal
653 a anastomotic leakage
653 a anorectal function
653 a costs
653 a resources
653 a Surgery
653 a Kirurgi
700a Matthiessen, Peter,c Docentu Region Örebro län4 ths
700a Hallböök, Olof4 ths
700a Mortensen, Neil,c Professoru Nuffield Department of Surgery, Oxford University, Storbritannien4 opn
710a Örebro universitetb Institutionen för medicinska vetenskaper4 org
856u https://oru.diva-portal.org/smash/get/diva2:910029/FULLTEXT01.pdfx primaryx Raw objecty fulltext
856u https://oru.diva-portal.org/smash/get/diva2:910029/COVER01.pdfy cover
856u https://oru.diva-portal.org/smash/get/diva2:910029/FULLTEXT02.pdfy spikblad
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-49021

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