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NLRP3 Inflammasome ...
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
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- Paramel Varghese, Geena, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Folkersen, Lasse (author)
- Department of Medicine and Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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- Halvorsen, Bente (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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- Yndestad, Arne (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway
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- Ranheim, Trine (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
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- Krohg-Sørensen, Kirsten (author)
- Department of Thoracic and Cardiovascular Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
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- Skjelland, Mona (author)
- Department of Neurology, Oslo University Hospital Rikshospitalet, Oslo, Norway
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- Espevik, Terje (author)
- Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway
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- Aukrust, Pål (author)
- Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway
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- Lengquist, Mariette (author)
- Karolinska Institutet
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- Hedin, Ulf (author)
- Karolinska Institutet
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- Jansson, Jan-Håkan (author)
- Department of Internal Medicine, Umeå University Hospital, Umeå, Sweden; Department of Internal Medicine, Skellefteå Hospital, Skellefteå, Sweden
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- Fransén, Karin, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Hansson, Göran K. (author)
- Karolinska Institutet
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- Eriksson, Per (author)
- Karolinska Institutet
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- Sirsjö, Allan, 1959- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
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(creator_code:org_t)
- Hoboken, USA : Wiley-Blackwell Publishing Inc. 2016
- 2016
- English.
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In: Journal of the American Heart Association. - Hoboken, USA : Wiley-Blackwell Publishing Inc.. - 2047-9980. ; 5:5
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
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- Background: The NLR family, pyrin domain containing 3 (NLRP3) inflammasome is an interleukin (IL)-1β and IL-18 cytokine processing complex that is activated in inflammatory conditions. The role of the NLRP3 inflammasome in the pathogenesis of atherosclerosis and myocardial infarction is not fully understood.Methods and Results: Atherosclerotic plaques were analyzed for transcripts of the NLRP3 inflammasome, and for IL-1β release. The Swedish First-ever myocardial Infarction study in Ac-county (FIA) cohort consisting of DNA from 555 myocardial infarction patients and 1016 healthy individuals was used to determine the frequency of 4 single nucleotide polymorphisms (SNPs) from the downstream regulatory region of NLRP3. Expression of NLRP3, Apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1 (CASP1), IL1B, and IL18 mRNA was significantly increased in atherosclerotic plaques compared to normal arteries. The expression of NLRP3 mRNA was significantly higher in plaques of symptomatic patients when compared to asymptomatic ones. CD68-positive macrophages were observed in the same areas of atherosclerotic lesions as NLRP3 and ASC expression. Occasionally, expression of NLRP3 and ASC was also present in smooth muscle cells. Cholesterol crystals and ATP induced IL-1β release from lipopolysaccharide-primed human atherosclerotic lesion plaques. The minor alleles of the variants rs4266924, rs6672995, and rs10733113 were associated with NLRP3 mRNA levels in peripheral blood mononuclear cells but not with the risk of myocardial infarction.Conclusions: Our results indicate a possible role of the NLRP3 inflammasome and its genetic variants in the pathogenesis of atherosclerosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Inflammasome
- interleukin-1b
- myocardial infarction
- NLRP3
- polymorphism
- Cardiology
- Kardiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Paramel Varghese ...
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Folkersen, Lasse
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Strawbridge, Ron ...
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Halvorsen, Bente
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Yndestad, Arne
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Ranheim, Trine
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Krohg-Sørensen, ...
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Skjelland, Mona
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Espevik, Terje
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Aukrust, Pål
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Lengquist, Marie ...
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Hedin, Ulf
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Jansson, Jan-Håk ...
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Fransén, Karin, ...
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Hansson, Göran K ...
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Eriksson, Per
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Sirsjö, Allan, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Journal of the A ...
- By the university
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Örebro University
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Karolinska Institutet