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Physical and verbal aggressive behavior and COMT genotype : Sensitivity to the environment

Tuvblad, Catherine, 1968- (author)
Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Department of Psychology, University of Southern California, Los Angeles CA, USA,Univ Orebro, Sch Law Psychol & Social Work, SE-70182 Orebro, Sweden.;Univ Southern Calif, Dept Psychol, Los Angeles, CA USA.
Narusyte, Jurgita (author)
Karolinska Institutet
Comasco, Erika (author)
Uppsala universitet,Institutionen för neurovetenskap
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Andershed, Henrik, 1975- (author)
Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Univ Orebro, Sch Law Psychol & Social Work, SE-70182 Orebro, Sweden.
Andershed, Anna-Karin, 1973- (author)
Örebro universitet,Institutionen för juridik, psykologi och socialt arbete,Univ Orebro, Sch Law Psychol & Social Work, SE-70182 Orebro, Sweden.
Colins, Olivier F. (author)
School of Law, Psychology and Social Work, Örebro University, Örebro, Sweden; Department of Child and Adolescent Psychiatry, Curium-Leiden University Medical Center, Leiden, The Netherlands,Univ Orebro, Sch Law Psychol & Social Work, SE-70182 Orebro, Sweden.;Curium Leiden Univ, Med Ctr, Dept Child & Adolescent Psychiat, Leiden, Netherlands.
Fanti, Kostas A. (author)
Department of Psychology, University of Cyprus, Nicosia, Cyprus,Univ Cyprus, Dept Psychol, Nicosia, Cyprus.
Nilsson, Kent W. (author)
Uppsala universitet,Centrum för klinisk forskning, Västerås
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 (creator_code:org_t)
2016-02-17
2016
English.
In: American Journal of Medical Genetics Part B. - Hoboken, USA : John Wiley & Sons. - 1552-4841 .- 1552-485X. ; 171:5, s. 708-718
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Catechol-O-methyltransferase (COMT) genotype has been implicated as a vulnerability factor for several psychiatric diseases as well as aggressive behavior, either directly, or in interaction with an adverse environment. The present study aimed at investigating the susceptibility properties of COMT genotype to adverse and favorable environment in relation to physical and verbal aggressive behavior. The COMT Val158Met polymorphism was genotyped in a Swedish population-based cohort including 1,783 individuals, ages 20-24 years (47% males). A significant three-way interaction was found, after correction for multiple testing, between COMT genotype, exposure to violence, and parent-child relationship in association with physical but not verbal aggressive behavior. Homozygous for the Val allele reported lower levels of physical aggressive behavior when they were exposed to violence and at the same time experienced a positive parent-child relationship compared to Met carriers. Thus, susceptibility properties of COMT genotype were observed in relation to physical aggressive behavior supporting the hypothesis that COMT genotypes are modifying the sensitivity to environment that confers either risk or protection for aggressive behavior. As these are novel findings, they warrant further investigation and replication in independent samples.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
SAMHÄLLSVETENSKAP  -- Psykologi (hsv//swe)
SOCIAL SCIENCES  -- Psychology (hsv//eng)

Keyword

COMT
aggression
physical
verbal
environmental
Psychiatry
Psykiatri

Publication and Content Type

ref (subject category)
art (subject category)

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