id:"swepub:oai:DiVA.org:oru-58056"
Search: id:"swepub:oai:DiVA.org:oru-58056" > Comorbidity and com...
- 1 of 1
- Previous record
- Next record
- To hitlist
Comorbidity and complications in neurological diseases
-
- Sundelin, Heléne E.K. 1965- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper
-
- Ludvigsson, Jonas F., professor, 1969- (thesis advisor)
- Örebro universitet,Institutionen för medicinska vetenskaper
-
- Larsson, Henrik, professor, 1975- (thesis advisor)
- Örebro universitet,Institutionen för medicinska vetenskaper
- show more...
- show less...
- (creator_code:org_t)
- ISBN 9789175291994
- Örebro : Örebro University, 2017
- English 81 s.
- Series: Örebro Studies in Medicine, 1652-4063 ; 163
- Doctoral thesis (other academic/artistic)
Abstract
Subject headings
Close
- Background: Neurological diseases are complex and many share etiology as well as comorbidities. Epilepsy, a brain disorder characterized by an enduring predisposition to generate epileptic seizures and autism spectrum disorder (ASD), are considered to be associated, but the connection is still not fully uncovered. Cerebral palsy (CP), a lifelong, nonspecific, non-progressive disorder of posture and movement control, and Ehlers-Danlos Syndrome (EDS), a connective tissue disorder, both have many consequences for health and wellbeing throughout life.Aims: The aim of this thesis was to explore the impact of comorbidity and complications in neurological diseases and EDS. The objective was to gain information on the nature of the connection between epilepsy and ASD, if EDS, ASD and CP have consequences for pregnancy outcome, and the risk of traffic accidents in individuals with epilepsy.Materials and methods: The studies are all historical observational population- based cohort studies with prospectively collected data from national registers. The risk of ASD was analysed in 85,201 individuals with epilepsy and compared with 425,760 controls as well as for their firstdegree relatives. In a cohort of 1,248,178 singleton births, 314 births to women with EDS, 2,072 births to women with ASD, and 770 births to women with CP, pregnancy outcome was explored. The risk of traffic accidents was estimated in 29,220 individuals with epilepsy and 267,637 matched controls.Results: There is an increased risk of; ASD in individuals with epilepsy and their relatives, moderately preterm birth and pre-eclampsia in maternal ASD, of preterm birth in maternal CP and transport accidents in individuals with epilepsy. There is no increased risk of adverse pregnancy outcome in women with EDS.Conclusions: This thesis found proofs of a bidirectional association between epilepsy and ASD, that ASD and CP have consequences for pregnancy outcome and epilepsy is a risk factor for traffic accidents.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Keyword
- antiepileptic drugs
- autism
- cerebral palsy
- child
- Ehlers-Danlos Syndrome
- epilepsy
- obstetric
- pregnancy
- traffic accidents
Publication and Content Type
- vet (subject category)
- dok (subject category)
Find in a library
- Comorbidity and complications in neurological diseases (Search the publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Sundelin, Heléne ...
- Ludvigsson, Jona ...
- Larsson, Henrik, ...
- Scott, Rodney, p ...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and General Practice
- Parts in the series
- Örebro Studies i ...
- By the university
- Örebro University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
