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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04301nam a2200445 4500 | |
| 001 | oai:DiVA.org:oru-585 | |
| 003 | SwePub | |
| 008 | 060828s2006 | |||||||||||000 ||eng| | |
| 020 | a 9176684946q print | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-5852 URI |
| 040 | a (SwePub)oru | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a vet2 swepub-contenttype |
| 072 | 7 | a dok2 swepub-publicationtype |
| 100 | 1 | a Dreifaldt, Ann Charlotte,d 1964-u Örebro universitet,Institutionen för klinisk medicin4 aut0 (Swepub:oru)ledt |
| 245 | 1 0 | a Epidemiological aspects on malignant diseases in childhood |
| 264 | 1 | a Örebro :b Örebro universitetsbibliotek,c 2006 |
| 300 | a 91 s. | |
| 338 | a print2 rdacarrier | |
| 490 | 0 | a Örebro Studies in Medicine,x 1652-4063 ;v 7 |
| 520 | a The trends of malignant diseases in children aged 0 to 14 years, reported to the Swedish Cancer Registry 1960–1998 (n=9 298) were analyzed. The most common diagnoses were leukemia, 29.7%, tumors of the central nervous system (CNS), 27.6%, and lymphomas, 10.2%. The average annual incidence rate of childhood malignant diseases 1990–1998 was 16.19/100 000 person-years. Average annual change in incidence rate of all childhood cancer was +1.01% (95% confidence interval (CI)=0.80-1.22). Statistically significant increase was seen for leukemia +0.85% (95% CI=0.42–1.28), lymphomas +1.87% (95% CI=1.17–2.58), CNS tumors +1.45% (95% CI=1.02–1.88), sympathetic nervous system tumors +1.61% (95% CI=0.79–2.44), hepatic tumors +2.62% (95% CI=2.02–3.21), and germ cell and gonadal tumors +1.21% (95% CI=0.23–2.19). Children are exposed to persistent organic pollutants (POPs) during fetal life and breast-feeding. In a case-control study including cases of childhood cancer reported to the Cancer Registry 1988–1991 (n=962) we used breastfeeding duration as a surrogate for exposure to POPs. One matched control per case was used. Information on breast-feeding, vaccinations and chronic illness was collected from copies of the children’s Child Health Center records. Overall, breast-feeding did not affect the risk of childhood cancer, OR=1.0 (95% CI=0.7–1.3) using breast-feeding up to one month as reference. For non-Hodgkin lymphoma (NHL) OR for breast-feeding for >1 month yielded OR=5.0 (95% CI=1.1–23). No association was seen between preschool vaccinations and childhood cancer except for lymphomas and measles/measles-mumps-rubella vaccination, OR=0.2 (95% CI=0.1–0.6). Increased risk of all cancer was found for congenital malformations, OR=1.7 (95% CI=0.97–2.9), especially of leukemia, OR=3.0 (95% CI=1.5–5.8). Children with disorders of brain function had an increased risk of all cancer, OR=6.0 (95% CI=1.3–27), especially of brain tumors, OR=10 (95% CI=1.3–78). A childhood population expected to be more exposed to POPs is children of fishermen. In a register-based study, the cancer incidence rates in a cohort of fishermen children (at age 0-19 years) were compared to the rates of referent children. A modestly increased incidence rate ratio (IRR) of childhood cancer was found, IRR=1.38 (95% CI=0.96–2.00) and an increased IRR for acute lymphoid leukemia, IRR=2.65 (95% CI=1.005–6.97). In west coast fishermen children, an increased IRR was observed for NHL, IRR=3.19 (95% CI=0.98–10.4). | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a childhood cancer | |
| 653 | a incidence rates | |
| 653 | a persistent organic pollutants | |
| 653 | a breast-feeding | |
| 653 | a MEDICINE | |
| 653 | a MEDICIN | |
| 653 | a Oncology | |
| 653 | a Onkologi | |
| 653 | a Medicin | |
| 653 | a Medicine | |
| 653 | a Onkologi | |
| 653 | a Oncology | |
| 700 | 1 | a Hardell, Lennart,c Professoru Örebro universitet,Institutionen för naturvetenskap4 ths |
| 700 | 1 | a Flodin, Ulf,c docentu Avd för yrkes- och miljömedicin, Inst för molekylär och klinisk medicin, Hälsouniversitetet, Linköping4 opn |
| 710 | 2 | a Örebro universitetb Institutionen för klinisk medicin4 org |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-585 |
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