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Association between...
Association between age, IL-10, IFN gamma, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes
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- Kaas, A. (author)
- Department of Paediatrics, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
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- Pfleger, C. (author)
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich-Heine University, Düsseldorf, Germany
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- Kharagjitsingh, A. V. (author)
- Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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- Schloot, N .C. (author)
- Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich-Heine University, Düsseldorf, Germany; Medical Faculty, Department of Metabolic Diseases, University of Düsseldorf, Düsseldorf, Germany
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- Hansen, L. (author)
- Department of Paediatrics, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
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- Buschard, K. (author)
- Bartholin Institute, Rigshospitalet, Copenhagen, Denmark
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- Koeleman, B. P. C. (author)
- Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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- Roep, B. O. (author)
- Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
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- Mortensen, H. B. (author)
- Department of Paediatrics, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
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- Alizadeh, B. Z. (author)
- Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
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- Åman, Jan, 1948- (author)
- Region Örebro län,Hvidøre Study Group on Childhood Diabetes, Copenhagen, Denmark
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(creator_code:org_t)
- 2012-05-16
- 2012
- English.
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In: Diabetic Medicine. - : Wiley-Blackwell. - 0742-3071 .- 1464-5491. ; 29:6, s. 734-741
- Related links:
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https://pure.rug.nl/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- AIMS: The relation of disease progression and age, serum interleukin 10 (IL-10) and interferon gamma (IFNγ) and their genetic correlates were studied in paediatric patients with newly diagnosed Type 1 diabetes.METHODS: Two hundred and twenty-seven patients from the Hvidoere Study Group were classified in four different progression groups as assessed by change in stimulated C-peptide from 1 to 6 months. CA repeat variants of the IL-10 and IFNγ gene were genotyped and serum levels of IL-10 and IFNγ were measured at 1, 6 and 12 months.RESULTS: IL-10 decreased (P < 0.001) by 7.7% (1 month), 10.4% (6 months) and 8.6% (12 months) per year increase in age of child, while a twofold higher C-peptide concentration at 1 month (p = 0.06), 6 months (P = 0.0003) and 12 months (P = 0.02) was associated with 9.7%, 18.6% and 9.7% lower IL-10 levels, independent of each other. IL-10 concentrations did not associate with the disease progression groups. By contrast, IFNγ concentrations differed between the four progression groups at 6 and 12 months (P = 0.02 and P = 0.01, respectively); patients with rapid progressing disease had the highest levels at both time points. Distribution of IL-10 and IFNγ genotypes was equal among patients from the progression groups.CONCLUSION: IL-10 serum levels associate inversely with age and C-peptide. As age and C-peptide also associate, a triangular association is proposed. Genetic influence on IL-10 production seems to be masked by distinct disease mechanisms. Increased serum IFNγ concentrations associate with rapid disease progression. Functional genetic variants do not associate with a single progression pattern group, implying that disease processes override genetically predisposed cytokine production.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- disease progression; interferon gamma; interleukin 10; Type 1 diabetes
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kaas, A.
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Pfleger, C.
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Kharagjitsingh, ...
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Schloot, N .C.
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Hansen, L.
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Buschard, K.
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Koeleman, B. P. ...
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Roep, B. O.
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Mortensen, H. B.
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Alizadeh, B. Z.
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Åman, Jan, 1948-
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Diabetic Medicin ...
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Örebro University