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Sökning: id:"swepub:oai:DiVA.org:oru-59088" > Severe infections a...

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FältnamnIndikatorerMetadata
00005441naa a2200529 4500
001oai:DiVA.org:oru-59088
003SwePub
008170814s2017 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:137106789
024a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-590882 URI
024a https://doi.org/10.1177/20474873177240092 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1371067892 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Bergh, Cecilia,d 1972-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)cbh
2451 0a Severe infections and subsequent delayed cardiovascular disease
264 c 2017-08
264 1b Sage Publications,c 2017
338 a print2 rdacarrier
500 a Funding Agency:UK Economic and Social Research Council (ESRC)  RES-596-28-0001  ES/JO19119/1
520 a Background: Severe infections in adulthood are associated with subsequent short-term cardiovascular disease. Whether hospital admission for sepsis or pneumonia is associated with persistent increased risk (over a year after infection) is less well established.Design: The design of this study was as a register-based cohort study.Methods: Some 236,739 men born between 1952-1956 were followed from conscription assessments in adolescence to 2010. All-cause cardiovascular disease ( n = 46,754), including coronary heart disease ( n = 10,279) and stroke ( n = 3438), was identified through national registers 1970-2010 (at ages 18-58 years).Results: Sepsis or pneumonia in adulthood (resulting in hospital admission) are associated with increased risk of cardiovascular disease in the years following infection. The risk is highest during the first year after the infection, with an adjusted hazard ratio (and 95% confidence intervals) of 6.33 (5.65-7.09) and a notably increased risk persisted with hazard ratios of 2.47 (2.04-3.00) for the second and 2.12 (1.71-2.62) for the third year after infection. The risk attenuated with time, but remained raised for at least five years after infection; 1.87 (1.47-2.38). The results are adjusted for characteristics in childhood, cardiovascular risk factors and medical history in adolescence. Similar statistically significant associations were found for coronary heart disease and stroke.Conclusions: Raised risks of cardiovascular disease following hospital admission for sepsis or pneumonia were increased for more than five years after the infection, but with the highest magnitude during the first three years following infection, suggesting a period of vulnerability when health professionals and patients should be aware of the heightened risk for cardiovascular disease.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng
653 a Adult infection
653 a cardiovascular disease
653 a risk factors
653 a sepsis
653 a stroke pneumonia
700a Fall, Katja,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)kafl
700a Udumyan, Ruzan,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)run
700a Sjöqvist, Hugo,d 1992-u Örebro universitet,Handelshögskolan vid Örebro Universitet,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)host
700a Fröbert, Ole,d 1964-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden4 aut0 (Swepub:oru)oft
700a Montgomery, Scott,d 1961-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, UK,Clinical Epidemiology and Biostatistics4 aut0 (Swepub:oru)smy
710a Örebro universitetb Institutionen för medicinska vetenskaper4 org
773t European Journal of Preventive Cardiologyd : Sage Publicationsg 24:18, s. 1958-1966q 24:18<1958-1966x 2047-4873x 2047-4881
856u https://doi.org/10.1177/2047487317724009y Fulltext
856u https://journals.sagepub.com/doi/pdf/10.1177/2047487317724009
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-59088
8564 8u https://doi.org/10.1177/2047487317724009
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:137106789

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